The chapter discusses dark matter, galaxy formation and evolution, black holes, and large-scale structure of the universe. Galaxy masses require more matter than can be seen to explain rotation and dynamics. Galaxies likely formed from mergers of smaller galaxies and star clusters. Collisions are important and may transform spiral galaxies into ellipticals over time. Quasars and active galaxies represent early stages, with normal galaxies as a later evolutionary phase. The universe exhibits structure up to 100-200 megaparsecs but appears uniform at larger scales.