Bioengineering: making life from scratch
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The document discusses the principles and applications of synthetic biology, emphasizing the need to build and understand biological systems through modeling, simulation, and experimentation. It highlights the significance of genetic engineering with references to notable projects and frameworks like the parts registry and biobricks foundation. The content also mentions advanced topics such as gene circuits and cellular behavior, illustrating the potential of bioengineering in various fields including life creation and biofuels.
![Bioengineering: making life from scratch Melanie Swan MS Futures Group +1-650-681-9482 [email_address] http://www.melanieswan.com Slides: http://slideshare.net/LaBlogga/slideshows NIH, Bethesda MD September 25, 2008 Must build it to understand it](https://image.slidesharecdn.com/synbio-1223083191201621-9/85/Bioengineering-making-life-from-scratch-1-320.jpg)
![Thank you Melanie Swan MS Futures Group +1-650-681-9482 [email_address] http://www.melanieswan.com Slides: http://slideshare.net/LaBlogga/slideshows NIH, Bethesda MD September 25, 2008](https://image.slidesharecdn.com/synbio-1223083191201621-9/85/Bioengineering-making-life-from-scratch-15-320.jpg)
Bioengineering: making life from scratch
- 1. Bioengineering: making life from scratch Melanie Swan MS Futures Group +1-650-681-9482 [email_address] http://www.melanieswan.com Slides: http://slideshare.net/LaBlogga/slideshows NIH, Bethesda MD September 25, 2008 Must build it to understand it
- 2. Synthetic biology Novel biological system
- 3. The new biology: virtuous feedback loop Model and simulate Investigate and experiment Build
- 4. Bio-SPICE Biological Simulation Program for Intra- and Inter-Cellular Evaluation http://biospice.org Model and simulate
- 5. Registry of Standard Biological Parts Build http://partsregistry.org
- 6. Parts Registry: select measurement device http://partsregistry.org
- 7. Parts Registry: obtain part sequence DNA Synthesizer http://partsregistry.org
- 8. The story of biocomputing Mapping genes to proteins -> life can be engineered Genes can be turned on and off -> gene as binary switch Systemic understanding of DNA -> genes as circuits Cell noisiness -> need for stable and predictable circuits
- 9. Repressilator schema “ Noisy” cells Michael Elowitz Stanislas Leibler Repressilator A synthetic oscillatory network of transcriptional regulators Michael B. Elowitz & Stanislas Leibler Nature. 2000 Jan 20;403(6767):335-38. http://www.nature.com/nature/journal/v403/n6767/full/403335a0.html
- 10. Construction of a genetic toggle switch in Escherichia coli Gardner TS, Cantor CR, Collins JJ Nature. 2000 Jan 20;403(6767):339-42. http://www.ncbi.nlm.nih.gov/pubmed/10659857 Toggle switch induction threshold Toggle switch plasmid Gardner Cantor Collins Genetic toggle switch
- 11. Open wetware Drew Endy Parts Registry BioBricks Foundation iGEM competition http://openwetware.org/ http://bbf.openwetware.org/ http://www.igem.org/ http://partsregistry.org
- 12. Genome Craig Venter Synthetic life Synthetic life Fourth-generation biofuels Mycoplasma genitalium Bacterial image Genetic map
- 13. Further applications of bioengineering Coli-roid microbial camera Landmine sensing plant: Arabidopsis thaliana Amorphous computing Cellular colonies Natural genetic engineering Ciliate
- 14. Summary Model and simulate Investigate and experiment Build
- 15. Thank you Melanie Swan MS Futures Group +1-650-681-9482 [email_address] http://www.melanieswan.com Slides: http://slideshare.net/LaBlogga/slideshows NIH, Bethesda MD September 25, 2008