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In the name of Allah the most
merciful and the most
beneficent
Course Title:

Diversity of Monera
Course Code:

BOT-301
Bioterrorism
OBJECTIVES
The main objectives of my presentation are:
To increase the awareness about;
  How it develops?
● Why and How it is increasing alarming      
   high rate?
●  Are they curable?
●  How to prevent them?
●  What we should do?
●
CONTENTS
 Definition
● History
● Early use
th
● 20  Century
st
● 21  Century
● Types of Agents
● Category A
● Category B
● Category C
● Planning and Response
● Preparedness
● Biosurveillance
● Response to Bioterrorism incident or Threat
●
Have you ever noticed this Sign
What is Bioterrorism
DEFINITION:-

A bioterrorism attack is the deliberate 
release of viruses, bacteria, toxins or other 
harmful agents used to cause illness or 
death in people, animals, or plants
These agents are typically found in 
nature, but it is possible that they 
could be changed to increase their 
ability to cause disease, make them 
resistant to current medicines, or to 
increase their ability to be spread into 
the environment.
Terrorists  may  use  biological 
agents  because  they  can  be 
extremely  difficult  to  detect  and 
do  not  cause  illness  for  several 
hours  to  several  days.  Some 
bioterrorism  agents,  like  the 
smallpox  virus,  can  be  spread 
from  person  to  person  and  some, 
like anthrax, can not.
Bioterrorism
HISTORY
Early use
Biological terrorism dates as far back as Ancient Rome , 
when  feces  were  thrown  into  faces  of  enemies.This 
early  version  of  biological  terrorism  continued  on  into 
the 14th century where the bubonic plague was used to 
infiltrate  enemy  cities,both  by  instilling  the  fear  of 
infection  in  residences,  in  hopes  that  they  would 
evacuate,  and  also  to  destroy  defending  forces  that 
would  not  yield  to  the  attack.  The  use  of  disease  as  a 
weapon  in  this  stage  of  history  exhibited  a  lack  of 
control  aggressors  had  over  their  own  biological 
weapons.  Primitive  medical  technology  provided 
limited  means  of  protection  for  the  aggressor  and  a 
battle's surrounding geographical regions.
After  the  battle  was  won,  the  inability  to 
contain  enemies  who  escaped  death  led  to 
widespread  epidemics  affecting  not  only  the 
enemy  forces,  but  also  surrounding  regions' 
inhabitants. Due to the use of these biological 
weapons,  and  the  apparent  lack  of  medical 
advancement 
necessary 
to 
defend 
surrounding  regions  from  them,  widespread 
epidemics  such  as  the bubonic plaguequickly 
moved across all of Europe, destroying a large 
portion of its population.
th

20 Century
By the time World War I  began, attempts to use 
anthrax  were directed at animal populations. This 
generally proved to be ineffective. Shortly after the 
start of World War I, Germany launched a biological 
sabotage campaign in the United States, Russia, 
Romania, and France.At that time, Anton Dilger  lived 
in Germany, but in 1915 he was sent to the United 
States carrying cultures ofglanders , a virulent disease 
of horses and mules. Dilger set up a laboratory in his 
home in Chevy Chase, Maryland . He used stevedores 
 working the docks in Baltimore to infect horses with
glanders  while they were waiting to be shipped to 
Britain.
Dilger was under suspicion as being a 
German agent, but was never arrested. 
Dilger eventually fled to Madrid, Spain, 
where he died during the Influenza 
Pandemic of 1918.In 1916, the Russians 
arrested a German agent with similar 
intentions. Germany and its allies infected 
French cavalry horses and many of 
Russia’s mules and horses on the Eastern 
Front. These actions hindered artillery and 
troop movements, as well as supply 
convoys.
1984­USA­Rajneeshee 
bioterror attack
In Oregon  in 1984, followers of the 
Bhagwan Shree Rajneesh  attempted to control a local 
election by incapacitating the local population. This 
was done by infecting salad  bars in 11 restaurants, 
produce in grocery stores, doorknobs, and other public 
domains with Salmonella typhimurium  bacteria in the 
city of The Dalles , Oregon . The attack infected 751 
people with severe food poisoning . However, there 
were no fatalities. This incident was the first known 
bioterrorist attack in the United States in the 20th 
century.
st

21 Century
2001 USA Anthrax attack
In September and October 2001, several cases of 
anthrax broke out in the United States  in the 2001 
anthrax attacks, caused deliberately. Letters laced 
with infectious anthrax were delivered to news media 
offices and the U.S Congress. The letters killed 5. Tests 
on the anthrax strain used in the attack pointed to a 
domestic source, possibly from the biological weapons 
program. Still the attacks provoked efforts to define 
biodefense  and biosecurity , where more limited 
definitions of biosafety  had focused on unintentional 
or accidental impacts of agricultural and medical 
technologies
Types of Agents
Under  current United States law  , bio­agents 
 which 
have 
been 
declared 
by 
the 
U.S. Department of Health and Human Services 
 or  the U.S. Department of Agriculture   to  have 
the  "potential  to  pose  a  severe  threat  to  public 
health  and  safety"  are  officially  defined  as  "
select agents  ".  The  CDC  categorizes  these  agents 
(A, 
B 
or 
C) 
and 
administers 
the 
Select Agent Program  ,  which  regulates  the 
laboratories  which  may  possess,  use,  or  transfer 
select agents within the United States.
Category A
These high­priority agents pose a risk to 
national security, can be easily transmitted and 
disseminated, result in high mortality, have 
potential major public health impact, may cause 
public panic, or require special action for public 
health preparedness.Category A includes:
● Tulameria
● Anthrax
● Small pox
● Botulinum toxin
● Bubonic plague
● Viral hemmoragic fever
TULAREMIA:
Tularemia, or rabbit fever, 
has a very low fatality rate 
if treated, but can severely 
incapacitate. The disease 
is caused by the 
Francisella tularensis 
 bacterium, and can be 
contracted through 
contact with the fur , 
inhalation, ingestion of 
contaminated water or 
insect bites. 
Francisella tularensis is very infectious. A small 
number (10­50 or so organisms) can cause 
disease. IfF. tularensis were used as a weapon, 
the bacteria would likely be made airborne for 
exposure by inhalation. People who inhale an 
infectious aerosol would generally experience 
severe respiratory illness, including life­
threatening pneumonia and systemic infection, 
if they are not treated. The bacteria that cause 
tularemia occur widely in nature and could be 
isolated and grown in quantity in a laboratory, 
although manufacturing an effective aerosol 
weapon would require considerable 
sophistication
ANTHRAX
Anthrax is a non­
contagious disease 
caused by the spore­
forming 
bacterium Bacillus 
anthracis. An 
anthrax vaccine  does 
exist but requires many 
injections for stable 
use.
When discovered early anthrax can be cured by 
administering antibiotics  (such as ciprofloxacin).Its 
first modern incidence in biological warfare were when 
Scandinavian "freedom fighters" supplied by the 
German General Staff used anthrax with unknown 
results against the Imperial Russian Army in Finland 
in 1916.In 1993, the Aum Shinrikyo  used anthrax in an 
unsuccessful attempt in Tokyo with zero 
fatalities.Anthrax was used in a series of attacks  on 
the offices of several United States Senators in late 
2001. The anthrax was in a powder form and it was 
delivered by the mail.Anthrax is one of the few 
biological agents that federal employees have been 
vaccinated for. The strain used in the 2001 anthrax 
attack was identical to the strain used by the 
USAMRIID.
Small pox
Smallpox is a highly contagious virus . It is transmitted easily 
through the atmosphere and has a high mortality rate  (20­
40%).Smallpox was eradicated  in the world in the 1970s, thanks to 
a worldwide vaccination program.
Small pox
However, some virus samples are still available in Russian  and 
American  laboratories. Some believe that after the collapse of the 
Soviet Union, cultures of smallpox have become available in other 
countries. Although people born pre­1970 will have been vaccinated 
for smallpox under the WHO program, the effectiveness of 
vaccination is limited since the vaccine provides high level of 
immunity for only 3 to 5 years. Revaccination's protection lasts 
longer.As a biological weapon smallpox is dangerous because of the 
highly contagious nature of both the infected and their pox. Also, the 
infrequency with which vaccines are administered among the 
general population since the eradication of the disease would leave 
most people unprotected in the event of an outbreak. Smallpox occurs 
only in humans, and has no external hosts or vectors.
Category B
Category B agents are moderately easy to 
disseminate and have low mortality rates.
● Q fever
● Typhus
● Styphylococcal
● Brucellosis
● Psittacosis
● Racin toxin from Ricinus communis (castor 
beans)
CATEGORY C
Category C agents are emerging pathogens 
that might be engineered  for mass 
dissemination because of their availability, 
ease of production and dissemination, high 
mortality rate, or ability to cause a major 
health impact.
● Nipah Virus
● Hanta Virus
● SARS
● H1N1 a strain of Influenza
● HIV/AIDS
H1N1
Bioterrorism
Planing and Response
Planning may involve the development of 
biological identification systems.Until 
recently in the United States , most biological 
defense strategies have been geared to 
protecting soldiers on the battlefield rather 
than ordinary people in cities. Financial 
cutbacks have limited the tracking of disease 
outbreaks. Some outbreaks, such as food 
poisoning due to E. coli  or Salmonella , could 
be of either natural or deliberate origin.
 

 
Bioterrorism
PREPAREDNESS
Biological agents are relatively easy to 
obtain  by  terrorists  and  are  becoming 
more  threatening  in  the  U.S.,  and 
laboratories  are  working  on  advanced 
detection  systems  to  provide  early 
warning,  identify contaminated areas 
 and  populations  at  risk,  and  to 
facilitate prompt treatment.
●
 

 
Methods for predicting the use of 
biological agents in urban areas as well as 
assessing the area for the hazards 
associated with a biological attack are 
being established in major cities.
●In addition, forensic technologies are 
working on identifying biological agents, 
their geographical origins and/or their 
initial son. 
●Efforts include decontamination 
technologies to restore facilities without 
causing additional environmental 
concerns.
●
Bioterrorism
BIOSURVEILLANCE
In  1999,  the University of Pittsburgh's  Center  for Biomedical 
 Informatics  deployed  the  first  automated  bioterrorism 
detection 
system, 
called 
RODS (Real­Time Outbreak Disease Surveillance)  .RODS  is 
designed to draw collect data from many data sources and use 
them  to  perform  signal  detection,  that  is,  to  detect  a  possible 
bioterrorism event at the earliest possible moment. RODS, and 
other systems like it, collect data from sources including clinic 
data,laboratory  data,  and  data  from  over­the­counter  drug 
sales.a subcontractor, conceived the idea of obtaining live data 
feeds  from  "non­traditional"  (non­health­care)  data  sources. 
The  RODS  laboratory's  first  efforts  eventually  led  to  the 
establishment  of  the  National  Retail  Data  Monitor,  a  system 
which collects data from 20,000 retail locations nation­wide
 

 
Bioterrorism
Response to Bioterrotism
Incident or Threat
Government agencies which would be called on to 
respond to a bioterrorism incident would include 
law  enforcement,  hazardous  materials  or 
decontamination  units  and  emergency  medical 
units.  The  US  military  has  specialized  units, 
which  can  respond  to  a  bioterrorism  event; 
among  them  are  the  US  Marine  Crop's  Chemical 
Biological  Incidence  Response  Force  and  the  US 
army's  20th  Supprot  Command(CBRNE),  which 
can  detect,  identify  and  neutralize  threats  and 
decontaminate  victims  exposed  to  bioterror 
agents.
In  Pakistan  no  proper  vaccination  is 
available......Recently 
many 
children 
nearly  210  has  died  due  to  Measles  in 
Karachi.
Govt. should take major steps against such 
diseases that spread out in our country.
Because  nothing  is  precious  than 
Health......!!!
COCNLUSION
 National level mass awareness            
  programs should be arranged.
● Practical steps should be taken.
● Every person must take care of           
  himself and his dear ones.
● Legislation should be made.
● Improve conditions of urban areas.
●
This is Black Biology

This is Black Biology
Bioterrorism

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Bioterrorism