This study investigates the entropy generation in fully developed laminar flow through a hexagonal duct subjected to constant heat flux, comparing water and engine oil as working fluids. It explores how fluid properties, duct aspect ratio, and heat flux affect entropy generation, and presents methods for minimizing entropy generation by adjusting the duct's cross-sectional shape. The results indicate that for both fluids, higher duct aspect ratios lead to decreased entropy generation, particularly influenced by the properties of the fluids used.