This white paper discusses migrating from Itanium/HP-UX platforms to x86/SUSE Linux Enterprise Server platforms. It argues that x86/SUSE Linux offers greater flexibility, interoperability, and ability to take advantage of innovations like virtualization and cloud computing at lower costs than Itanium/HP-UX. The paper cites declining market share and support for Itanium as reasons for uncertainty around its future. It provides a detailed comparison of features available on SUSE Linux versus HP-UX and argues that SUSE Linux now meets or exceeds HP-UX in performance, reliability, and scalability. The paper concludes that migrating to x86/SUSE Linux is the best path for data center modernization.