CPCSEA Guidelines
Download as PPT, PDF520 likes258,998 views
This document discusses the Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA), which is a statutory body formed under the Prevention of Cruelty to Animals Act in India. It oversees animal experimentation through Institutional Animal Ethics Committees (IAEC). The CPCSEA introduces guidelines for animal housing, care, experimental facilities, and promotes the 3R principles of replacement, reduction and refinement of animal use in research. It is composed of scientists, regulators and animal activists who monitor compliance through IAECs at the institutional level.
CPCSEA Guidelines
- 1. DR. SAHIL KUMAR MAULANA AZAD MEDICAL COLLEGE CPCSEA GUIDELINES
- 2. CPCSEA Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA) Statutory body formed by the Act of the Indian Parliament under the Prevention of Cruelty to Animals Act, 1960 Formed in 1964 Revived in 1998, under the committed chairpersonship of Meneka Gandhi Head quarters at Chennai Includes various guidelines and sub committees
- 3. CPCSEA National level expert committee to scrutinize and approve the research projects conducted using animals. Introduced a national “Good Laboratory Practice” document Introduced the credo of 3R principles 2004 – CPCSEA officially accepts the concept of the 4th R “investigators have a moral responsibility to take care of laboratory animals after use”
- 4. CPCSEA This committee is composed of Members of the scientific community Regulatory authorities Animal activists. The committee has 10 experts and 3 official members
- 5. Ministry of Environment and Forests (Animal welfare) CPCSEA IAEC IBSC/IBC IAEC:Institutional animals ethical committee IBSC/IBC:Institutional biosafety ethical committee
- 6. CPCSEA and IAEC Role of CPCSEA is to monitor animal experiments through ethics committees set up in institutions(IAEC) CPCSEA Nominee –important link between CPCSEA and IAEC IAEC scrutinize all project proposals for experimentation on animals. For small animals- give the final approval For large animals- make its recommendation to SCLA (Sub-Committee on Large Animals)
- 7. IAEC composition --A Biological Scientist. --Two Scientists from different bio disciplines. --A Veterinarian involved in care of Animals. --Scientist In-Charge of Animal House Facility. The Chairman (preferably Head of the Institution / Department) and Member Secretary need to be nominated from the above five members. Other members : Main Nominee, Link Nominee, Scientist from outside and Socially Aware Nominee nominated by CPCSEA. The validity of IAEC is for 3 years.
- 8. CPCSEA Goals: To promote the humane care of animals used in research. To provide specifications that will enhance animals well being and quality of research. Objective: Effective functioning of Institutional animal ethical committee
- 9. Main Activities Registration of establishments for experiments on animals for Breeding of animals Approval of Animal House Facilities Permission of Committee for Conducting Experiments
- 10. CPCSEA guidelines Veterinary care: Provided by a veterinarian Daily observation of animals adopted Quarantine, Stabilization and Separation: Quarantine period for small lab animals : one wk to one mth- large lab animals : up to 6 weeks Physiologic, psychological and nutritional stabilization required Physical separation of animals by species to prevent anxiety and behavioral changes
- 11. Animal procurement and tranportation Procurement of animals done from established commercial animal vendors. During transport, stress avoided by: Use of transport containers (cages or crates) of appropriate size Permissible number of animals accommodated in each container
- 12. Experimental area: Experiments should be carried out in a separate area away from the place where they are housed. Separate functional areas for surgical support treatment of animals post operative and intensive care
- 13. Physical facilities Building materials Durable, moisture- proof, fire resistant and pest resistant Corridor(s) Wide enough to facilitate the movement of personnel and equipment Animal room doors Should fit properly , should not be rust Exterior windows Windows are not recommended Floors Smooth, moisture proof , nonabsorbent, skid proof floors Drains Proper drainage, Floors should be sloped Storage areas Designed for feed, bedding, cages and materials not in use.
- 14. Environment Temperature Humidity control between 18-29o C range of 30-70% Ventilation designed with 12-15 air cycles per hour. Power and lighting System should be safe Fluorescent lights are efficient Emergency backup needed Noise control noise free environment Concrete walls are more effective
- 15. Animal husbandry CAGING OR HOUSING SYSTEM The housing system should provide Adequate space,freedom of movement,normal postural adjustments Comfortable environment Easy access to food and water Adequate ventilation
- 16. Food and water Food should be palatable, non-contaminated, and nutritionally adequate Should have continuous access to fresh, potable uncontaminated drinking water Feed should contain Feed should not contain moisture crude fibre, crude protein and crude fat essential bits, minerals, carbohydrates insecticides, hormones, antibiotics, fumigants or potential toxicants. heavy metals
- 17. Bedding Should be absorbent, free from toxic chemicals Should be removed and replaced periodically with fresh materials Ideal to change the bedding twice a week
- 18. Sanitation and cleanliness Animal rooms, corridors, storage spaces, and other areas should be cleaned with appropriate detergents and disinfectants Wastes should be removed regularly and frequently (waste disposal – incineration) Cages should be sanitized before animals are placed in them
- 19. Proper maintence of records must Should maintain the SOP’s Proper selection of animal facility staff required Anaesthesia should be complete and without any pain Euthanasia :done when animal required to be sacrificed or termination of an experiment or otherwise for ethical reasons
- 20. Thank you
Editor's Notes
- #6: recombinant DNA, infectious agents, and other potentially hazardous biologics carries inherent safety risks. Working at an appropriate biosafety containment level and with the appropriate safety precautions is essential for mitigating those risks.