Dr. A. Sumathi - CPCSEA Guidelines.pdf
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The CPCSEA is a statutory body established under the Prevention of Cruelty to Animals Act of 1960 to oversee animal experimentation in India. It ensures ethical treatment of laboratory animals through guidelines for projects, veterinary care, housing, and sanitation practices, while promoting the principles of humane research. The committee consists of a diverse group including scientists, regulatory authorities, and animal activists, aimed at enhancing animal welfare and research quality.
Dr. A. Sumathi - CPCSEA Guidelines.pdf
- 1. CPCSEA GUIDELINES BALAN NANDU 1 CPCSEA GUIDELINES Committee for the Purpose of Control and Supervision of Experiments on Animals 1. Statutory body formed by the Act of the Indian Parliament under the Prevention of Cruelty to Animals Act, 1960 2. Formed in 1964 3. Revived in 1998, under the committed chairpersonship of Meneka Gandhi 4. Headquarters at Chennai 5. Includes various guidelines and sub committees 6. CPCSEA – National level expert committee to scrutinize and approve the research projects conducted using animals 7. Introduced a national “Good Laboratory Practice” document 8. Introduced the credo of 3R principles 2004 – CPCSEA officially accepts the concept of the 4th R “investigators have a moral responsibility to take care of laboratory animals after use” 9. This committee is composed of Members of the scientific community Regulatory authorities Animal activists The committee has 10 experts and 3 official members 10. Ministry of Environment and Forests (Animal welfare) – CPCSEA IAEC – Institutional animals ethical committee IBSC/IBC - Institutional biosafety ethical committee 11. CPCSEA and IAEC Role of CPCSEA is to monitor animal experiments through ethics committees set up in institutions (IAEC) CPCSEA Nominee – important link between CPCSEA and IAEC IAEC scrutinize all project proposals for experimentation on animals For small animals- give the final approval For large animals- make its recommendation to SCLA (Sub-Committee on Large Animals) 12. IAEC composition A Biological Scientist Two Scientists from different bio disciplines A Veterinarian involved in care of Animals Scientist In-Charge of Animal House Facility The Chairman (preferably Head of the Institution / Department) and Member Secretary need to be nominated from the above five members Other members: Main Nominee, Link Nominee, Scientist from outside and Socially Aware Nominee nominated by CPCSEA The validity of IAEC is for 3 years 13. CPCSEA Goals To promote the humane care of animals used in research To provide specifications that will enhance animals well being and quality of research Objectives – Effective functioning of Institutional animal ethical committee
- 2. CPCSEA GUIDELINES BALAN NANDU 2 14. Main Activities Registration of establishments i. for experiments on animals ii. for Breeding of animals Approval of Animal House Facilities Permission of Committee for Conducting Experiments 15. CPCSEA guidelines – Veterinary care Provided by a veterinarian Daily observation of animals adopted 16. CPCSEA guidelines – Quarantine, Stabilization and Separation Quarantine period for small lab animals – one week to one month Quarantine period for large lab animals – up to 6 weeks Physiologic, psychological, and nutritional stabilization required Physical separation of animals by species to prevent anxiety and behavioral changes 17. Animal procurement and transportation Procurement of animals done from established commercial animal vendors During transport, stress avoided by Use of transport containers (cages or crates) of appropriate size Permissible number of animals accommodated in each container 18. Experimental area Experiments should be carried out in a separate area away from the place where they are housed Separate functional areas for Surgical support Treatment of animals Post operative and intensive care 19. Physical facilities Building materials – Durable, moisture- proof, fire resistant and pest resistant Corridor(s) – Wide enough to facilitate the movement of personnel and equipment Animal room doors should fit properly; It should not be rust Exterior windows – Windows are not recommended Floors – Smooth, moisture proof, non-absorbent, skid proof floors Drains – Proper drainage; Floors should be sloped Storage areas – Designed for feed, bedding, cages, and materials not in use 20. Environment Temperature Humidity control between 18-29o C range of 30-70% Ventilation designed with 12-15 air cycles per hour Power and lighting System should be safe Fluorescent lights are efficient Emergency backup needed Noise control – noise free environment Concrete walls are more effective
- 3. CPCSEA GUIDELINES BALAN NANDU 3 21. Animal husbandry – CAGING OR HOUSING SYSTEM The housing system should provide Adequate space, Freedom of movement Normal postural adjustments Comfortable environment Easy access to food and water Adequate ventilation 22. Food and water Food should be palatable, non-contaminated, and nutritionally adequate Should have continuous access to fresh, potable uncontaminated drinking water Feed should contain essential bits, minerals, carbohydrates Feed should not contain moisture, crude fibre, crude protein and crude fat, insecticides, hormones, antibiotics, fumigants or potential toxicants, heavy metals 23. Bedding Should be absorbent Should be free from toxic chemicals Should be removed and replaced periodically with fresh materials Ideal to change the bedding twice a week 24. Sanitation and cleanliness Animal rooms, corridors, storage spaces, and other areas should be cleaned with appropriate detergents and disinfectants Wastes should be removed regularly and frequently (waste disposal – incineration) Cages should be sanitized before animals are placed in them 25. Proper maintenance of records Should maintain the SOP’s (Standard Operating Procedure) Proper selection of animal facility staff required Anaesthesia should be complete and without any pain Euthanasia – can be done when animal required to be sacrificed or termination of an experiment or otherwise for ethical reasons