Design schools have the potential to play an important role as agents of sustainable change by establishing Design Labs within each school. Design Labs can help facilitate new open and collaborative design networks by using student and teacher skills to investigate local sustainability initiatives, support co-design processes, provide visions and proposals, communicate solutions, empower communities, replicate promising models, and synergize systemic changes. For example, the Nutrire Milano project in Milan demonstrates how a Design Lab is supporting the regeneration of short food supply chains in the city.