This document discusses open system thinking and natural computation from an info-computationalism perspective. It provides background on the author and their research interests in computing paradigms, natural/unconventional computing, information dynamics, and computational aspects of science. Key concepts covered include complexity, emergence, self-organization, generative models, agent-based models, and viewing information and computation as the primary stuff and dynamics of the universe respectively. Examples are given of complexity arising from simplicity and adaptive complex systems.