This issue brief discusses students with disabilities who are at greatest risk of poor employment outcomes after high school. Decades of research show that students with disabilities often have difficulty finding employment after leaving school. The brief aims to identify the specific factors that put certain students at highest risk of unemployment through analysis of a national dataset. It also seeks to determine what schools can do to help mitigate risks, such as increasing vocational education opportunities and integration with non-disabled peers. The goal is to generate new knowledge that can inform more effective school interventions and strategies to improve postschool job prospects for students facing the greatest challenges.