This document presents a guide to good practices in e-learning based on 13 case studies from European regions. It discusses the benefits of e-learning including its potential to enrich education, provide flexibility and accessibility, and its role in addressing skills needs. The case studies illustrate emerging benefits and future possibilities to guide policymakers. They are structured to emphasize lessons learned and innovations. Key benefits highlighted include e-learning becoming a major part of education delivery, facilitating discovery and blended learning, addressing skills needs of SMEs and rural populations, and the role of regional collaboration. The guide is divided into sections on e-learning applications for all citizens, schools/universities, SMEs, the unemployed, and specialists.