This document summarizes key concepts in epidemiological studies. It discusses how epidemiological studies aim to determine the differences between those who get a disease and those who are spared. This is done by investigating the nature and extent of the disease, causative agents, sources of infection, modes of transmission and susceptibility of the population. The document also outlines the two main approaches in epidemiological investigations - asking questions and making comparisons. It provides examples of the types of questions asked and comparisons that can be made, such as between rural and urban populations. Finally, it defines epidemiological terms like case counts, rates, ratios and proportions that are used to measure and compare health outcomes.