GraphSummit | London | November 14th, 2023
Empowering AZ’s
Data Connectivity
Building an Internal Knowledge Graph Service
to foster Knowledge Graph projects, enhancing
Data Reusability with Federated Queries, and
harvesting LLM power to talk to the Graphs
Antonio Fabregat, PhD
Knowledge Graph Lead
Enterprise Data Office, IGNITE (AZ)
Presentation
Outline
• Revolutionizing Data Management
• Internal deployment of the Graph as a Service capability
• A view of the current AZ´s Knowledge Graph project landscape
• Queries Federation across several Knowledge Graphs
• Harvesting LLM power to talk to the graphs
2
Revolutionizing
Data Management
3
Tackling Data Growth with Knowledge Graphs
4
• Drug Discovery and Research Data
• Genomic and proteomic data, high-throughput screening results, clinical trial data, etc.
• Real-World Evidence and Patient Data
• Electronic health records (EHRs), wearable devices and remote monitoring, patient-reported outcomes, etc.
• And more…
Rapid data growth from various sources
• Data management
• Analysis tools
Increasing need for efficient
• Organize and structure data
• Facilitate easier access and analysis
Knowledge Graphs as a solution
Knowledge Graphs vs Traditional Data Management Systems
5
•Struggle with complex relationships and semantics
•Limited in capturing meaning and context
Traditional data management systems
•Excel at representing relationships and semantics
•Understand meaning and context of data
•Enable more effective analysis and insights
Knowledge graphs advantages
AI and Machine Learning with Knowledge Graphs
6
Increasing use of AI and
machine learning
in Data Analysis
•Need for efficient data representation
and processing
Knowledge Graphs
as a Solution
•Enriched data model
•Enhance AI and machine learning
algorithms' understanding
•Improve data analysis capabilities
Data Integration and Interconnectivity
7
Seamless integration of data from various sources
• Creation of a unified view of information
Overcoming Data Silos
•Interconnectivity of Knowledge Graphs
Increased value from Data Assets
•Enhanced Data Analysis and Insights
•Improved Decision-Making
Enhanced Search and Discovery
8
Improved Search and
Discovery Capabilities
More intuitive Query Languages
Uncovering hidden
relationships within data
Accurate and Relevant
Search Results
Enhanced user experience
Increased productivity
Personalisation and Recommendation
9
• Rich data representation and relationship mapping
Understanding user preferences, behaviour, and context
• Relevant content based on user interests
Personalized and targeted recommendations
• Improved customer satisfaction and retention
Increased user engagement
Knowledge Graphs representation alternatives
10
* Adapted from documentation at W3C https://www.w3.org/
Two ways of representing/storing a Knowledge Graph
RDF-star (Resource Description Framework)
Semantic Web: Good for common standards and data exchange
Data model based on 3 parts: subject, predicate and objects
Nodes’ properties added as predicates. Edges with properties are “triple-resources” (like “meta-nodes”)
Storage: “Triple/Quad Stores” Graph Databases
Any type of real-world information, can be represented in a Knowledge Graph
18 nodes (5 instances, 4 classes, 8 literals, 1 triple-resource)
19 relationships (triples)
Knowledge Graph is a way of organizing data & information in the form of a graph
A collection of interlinked concepts, entities, events that represent a network of real-world entities, the relationships between them.
LPG (Labelled-Property Graph)
Good for highly dynamic, transactional use cases
Data organized as nodes, labels, relationships and properties
Both nodes and edges can have properties
Storage: Native Graph Databases
5 nodes (5 ids, 4 Labels, 8 properties)
4 relationships (2 properties)
Internal
Graph as a Service
capability
11
Why Knowledge Graphs? and why a Service?
12
• Data management and analysis
• Overcoming data silos and integration challenges
Growing importance of knowledge graphs
• Hosting and development support for knowledge graphs
• Robust and scalable solutions
• Enhanced data-driven decision-making
Need for efficient and reliable services
• Improved data accessibility and insights
• Streamlined collaboration and innovation
Benefits for businesses and organizations
A view of the AZ´s
Knowledge Graph
Project Landscape
13
Biology | Market Strategy | Logistics | Environmental targets
14
Biological Insights
Knowledge Graph
Graph machine learning to help scientists
make faster & better drug discovery decisions
Competitive Intelligence
Knowledge Graph
One-stop-shop for competitive intelligence,
transforming a manual system into a rich service
Supply Chain
Knowledge Graph
Insights into the company’s supply chain,
streamlining processes to enhance decision-making
Sustainability
Initiative
Decision-making support system aiming to
reduce the company’s carbon footprint
Compounds
15
Compounds Synthesis
& Management
(CSMKG)
Combine several databases
Transforms operational data into business
insights to drive continuous improvements
in storage, logistics and delivery
High Throughput
Screening
(HTSKG)
Contains >£45 million worth of data
Increases the quality and efficiency
of future HTS screens
Compounds
& Fragments
(CFKG)
Creates a view of the chemical space
like a medicinal or computation chemist.
Contains all internal and selected external
libraries and allows users to modify a
search and receive feedback ‘live’
PharmaSci
16
Formulation
Knowledge Graph
Pre-clinical formulation design process
Leading to quicker, more effective
scientific developments
Boston Formulation
Knowledge Graph
Improves the understanding of our data
Enhances collaboration by breaking down
silos and connecting disparate data sources
Lipid Nano Particles
Knowledge Graph
Machine learning models
Predicts in-vivo activity from in-vitro
data for intra-cellular drug delivery
and LNP formulation design
Queries
Federation
across several
Knowledge
Graphs
17
Siloed data looks like…
18
19
Let’s build bridges to connect “siloes” of interest…
Query federation describes a collection of
features that enable users and systems to
run queries against multiple siloed data
sources without needing to migrate all data
to a unified system.
Federated Queries
are these BRIDGES
20
Let’s build bridges to connect “siloes” of interest…
The diagram shows the resulting subgraph for
the federated query that answers the question
“Find all genes in BIKG linked with a specific disease, and then
all trials in CIKG that are testing drugs targeting those genes”
Biological Insights
Knowledge Graph
Competitive Intelligence
Knowledge Graph
CIKG
Harvesting
LLM power to
talk to the
graphs
21
22
AZ Insights Chat
Acknowledgments
• Aaron Holt
• Nicolas Mervaillie
• Joe Depeau
• Job Maelane
• Yuen Leung Tang
• Jesus Barrasa
• Daniel Addison
• Delyan Ivanov
• Suzy Jones
• Wolfgang Klute
• Michael Lainchbury
• Andriy Nikolov
• Nishank Mahore
• Cristina Mihetiu
• Justin Morley
• Michaël Ughetto
• Lauren Eardley
• Karen Roberts
• Anthony Puleo
• Cinthia Willaman
• Ivan Figueroa
• Carlos Mercado
• Jorge Gutierrez
• Koushik Srinivasan
Enterprise Data Office | IGNITE
Enterprise Knowledge Graph Service
Robert Hernandez
Knowledge Engineering
Lead
Sandra Carrasco
Senior Knowledge
Graph Engineer
Antonio Fabregat
Knowledge Graph Lead
Ronnie Mubayiwa
Senior DevOps Engineer
Varun Bhandary
Senior Solution Architect
Sree Balasubramanyam
Senior IT Project Manager
Vishal Kumar
DevOps Engineer
Preetha Mutharasu
Knowledge Graph
Engineer
Prem Oliver Vincent
Scrum Master
Andy Stafford-Hughes
Testing Manager
Umapathy Boopathy
Cloud Solution Architect
Pascual Lorente
Senior Knowledge
Graph Engineer

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  • 1. GraphSummit | London | November 14th, 2023 Empowering AZ’s Data Connectivity Building an Internal Knowledge Graph Service to foster Knowledge Graph projects, enhancing Data Reusability with Federated Queries, and harvesting LLM power to talk to the Graphs Antonio Fabregat, PhD Knowledge Graph Lead Enterprise Data Office, IGNITE (AZ)
  • 2. Presentation Outline • Revolutionizing Data Management • Internal deployment of the Graph as a Service capability • A view of the current AZ´s Knowledge Graph project landscape • Queries Federation across several Knowledge Graphs • Harvesting LLM power to talk to the graphs 2
  • 4. Tackling Data Growth with Knowledge Graphs 4 • Drug Discovery and Research Data • Genomic and proteomic data, high-throughput screening results, clinical trial data, etc. • Real-World Evidence and Patient Data • Electronic health records (EHRs), wearable devices and remote monitoring, patient-reported outcomes, etc. • And more… Rapid data growth from various sources • Data management • Analysis tools Increasing need for efficient • Organize and structure data • Facilitate easier access and analysis Knowledge Graphs as a solution
  • 5. Knowledge Graphs vs Traditional Data Management Systems 5 •Struggle with complex relationships and semantics •Limited in capturing meaning and context Traditional data management systems •Excel at representing relationships and semantics •Understand meaning and context of data •Enable more effective analysis and insights Knowledge graphs advantages
  • 6. AI and Machine Learning with Knowledge Graphs 6 Increasing use of AI and machine learning in Data Analysis •Need for efficient data representation and processing Knowledge Graphs as a Solution •Enriched data model •Enhance AI and machine learning algorithms' understanding •Improve data analysis capabilities
  • 7. Data Integration and Interconnectivity 7 Seamless integration of data from various sources • Creation of a unified view of information Overcoming Data Silos •Interconnectivity of Knowledge Graphs Increased value from Data Assets •Enhanced Data Analysis and Insights •Improved Decision-Making
  • 8. Enhanced Search and Discovery 8 Improved Search and Discovery Capabilities More intuitive Query Languages Uncovering hidden relationships within data Accurate and Relevant Search Results Enhanced user experience Increased productivity
  • 9. Personalisation and Recommendation 9 • Rich data representation and relationship mapping Understanding user preferences, behaviour, and context • Relevant content based on user interests Personalized and targeted recommendations • Improved customer satisfaction and retention Increased user engagement
  • 10. Knowledge Graphs representation alternatives 10 * Adapted from documentation at W3C https://www.w3.org/ Two ways of representing/storing a Knowledge Graph RDF-star (Resource Description Framework) Semantic Web: Good for common standards and data exchange Data model based on 3 parts: subject, predicate and objects Nodes’ properties added as predicates. Edges with properties are “triple-resources” (like “meta-nodes”) Storage: “Triple/Quad Stores” Graph Databases Any type of real-world information, can be represented in a Knowledge Graph 18 nodes (5 instances, 4 classes, 8 literals, 1 triple-resource) 19 relationships (triples) Knowledge Graph is a way of organizing data & information in the form of a graph A collection of interlinked concepts, entities, events that represent a network of real-world entities, the relationships between them. LPG (Labelled-Property Graph) Good for highly dynamic, transactional use cases Data organized as nodes, labels, relationships and properties Both nodes and edges can have properties Storage: Native Graph Databases 5 nodes (5 ids, 4 Labels, 8 properties) 4 relationships (2 properties)
  • 11. Internal Graph as a Service capability 11
  • 12. Why Knowledge Graphs? and why a Service? 12 • Data management and analysis • Overcoming data silos and integration challenges Growing importance of knowledge graphs • Hosting and development support for knowledge graphs • Robust and scalable solutions • Enhanced data-driven decision-making Need for efficient and reliable services • Improved data accessibility and insights • Streamlined collaboration and innovation Benefits for businesses and organizations
  • 13. A view of the AZ´s Knowledge Graph Project Landscape 13
  • 14. Biology | Market Strategy | Logistics | Environmental targets 14 Biological Insights Knowledge Graph Graph machine learning to help scientists make faster & better drug discovery decisions Competitive Intelligence Knowledge Graph One-stop-shop for competitive intelligence, transforming a manual system into a rich service Supply Chain Knowledge Graph Insights into the company’s supply chain, streamlining processes to enhance decision-making Sustainability Initiative Decision-making support system aiming to reduce the company’s carbon footprint
  • 15. Compounds 15 Compounds Synthesis & Management (CSMKG) Combine several databases Transforms operational data into business insights to drive continuous improvements in storage, logistics and delivery High Throughput Screening (HTSKG) Contains >£45 million worth of data Increases the quality and efficiency of future HTS screens Compounds & Fragments (CFKG) Creates a view of the chemical space like a medicinal or computation chemist. Contains all internal and selected external libraries and allows users to modify a search and receive feedback ‘live’
  • 16. PharmaSci 16 Formulation Knowledge Graph Pre-clinical formulation design process Leading to quicker, more effective scientific developments Boston Formulation Knowledge Graph Improves the understanding of our data Enhances collaboration by breaking down silos and connecting disparate data sources Lipid Nano Particles Knowledge Graph Machine learning models Predicts in-vivo activity from in-vitro data for intra-cellular drug delivery and LNP formulation design
  • 18. Siloed data looks like… 18
  • 19. 19 Let’s build bridges to connect “siloes” of interest… Query federation describes a collection of features that enable users and systems to run queries against multiple siloed data sources without needing to migrate all data to a unified system. Federated Queries are these BRIDGES
  • 20. 20 Let’s build bridges to connect “siloes” of interest… The diagram shows the resulting subgraph for the federated query that answers the question “Find all genes in BIKG linked with a specific disease, and then all trials in CIKG that are testing drugs targeting those genes” Biological Insights Knowledge Graph Competitive Intelligence Knowledge Graph CIKG
  • 21. Harvesting LLM power to talk to the graphs 21
  • 23. Acknowledgments • Aaron Holt • Nicolas Mervaillie • Joe Depeau • Job Maelane • Yuen Leung Tang • Jesus Barrasa • Daniel Addison • Delyan Ivanov • Suzy Jones • Wolfgang Klute • Michael Lainchbury • Andriy Nikolov • Nishank Mahore • Cristina Mihetiu • Justin Morley • Michaël Ughetto • Lauren Eardley • Karen Roberts • Anthony Puleo • Cinthia Willaman • Ivan Figueroa • Carlos Mercado • Jorge Gutierrez • Koushik Srinivasan
  • 24. Enterprise Data Office | IGNITE Enterprise Knowledge Graph Service Robert Hernandez Knowledge Engineering Lead Sandra Carrasco Senior Knowledge Graph Engineer Antonio Fabregat Knowledge Graph Lead Ronnie Mubayiwa Senior DevOps Engineer Varun Bhandary Senior Solution Architect Sree Balasubramanyam Senior IT Project Manager Vishal Kumar DevOps Engineer Preetha Mutharasu Knowledge Graph Engineer Prem Oliver Vincent Scrum Master Andy Stafford-Hughes Testing Manager Umapathy Boopathy Cloud Solution Architect Pascual Lorente Senior Knowledge Graph Engineer