This document provides information on intraosseous vascular access. It discusses indications for IO insertion including cardiac arrest, deteriorating patient, trauma, and inability to obtain IV access. It reviews safe insertion of the EZ-IO needle including equipment, sites, and steps. Potential risks and complications are outlined. Drugs and fluids that can be administered via IO are noted. Practical tips are provided such as pushing fluids due to resistance. Patient safety tips emphasize obtaining definitive venous access when possible and removing the IO.