This document discusses assessing liquid overflow in storage tanks using fluid-structure interaction (FSI) analysis. It presents an FSI-based analysis of overflow for a seismically isolated nuclear liquid storage tank. The analysis couples a fluid solver to model liquid sloshing with a structural solver to model the tank. Mass flow rate at the tank openings is calculated and used to determine total cumulative overflow volume over time. The method is demonstrated on a rectangular spent fuel pool model subjected to earthquakes. Results show significantly more overflow for a peak ground acceleration of 0.5g compared to 0.3g, highlighting the importance of accounting for seismic loading uncertainty.