This article discusses how companies can optimize existing technologies and processes to do more with less. It provides examples from AstraZeneca, a large pharmaceutical company, and discusses how they have improved production efficiency through lean methodology. The company reduced setup times by 75-90% with no new equipment by standardizing work and reducing changeover times. It also discusses how optimization, not new technology, can provide gains. Experts note that refinement of existing technologies and asking how to get more from what you have can provide solutions to future challenges.