Missions.me is a faith-based international non-profit that has transitioned to using Laravel for its web applications, enhancing their platform and improving user experience. The organization has faced and addressed various technical challenges such as timezones, database relationships, big data issues, permission management, and security concerns, employing Laravel features and custom solutions. Looking ahead, Missions.me plans to refactor its codebase, upgrade to Laravel 5.1, and further innovate its architecture and user interface.