The document discusses the integration of reservoir uncertainties into flow assurance strategies, highlighting the importance of rigorous thermal hydraulic models to improve facilities design and manage risks related to issues such as hydrate management. It details a methodology using the Taguchi method for experimental design to optimize simulations and reduce unnecessary computational runs, ultimately aiding in predicting cooldown times. The conclusion emphasizes the need for a collaborative approach between facilities and subsurface engineers, incorporating statistical methods to ensure design decisions reflect realistic scenarios rather than overly conservative assumptions.