The document summarizes an interview with Antonio Nieto-Rodriguez, the Director of Program Management Office at GlaxoSmithKline Vaccines. Some of the biggest challenges facing program managers include overcoming a lack of understanding about the value of program management from executive teams and perceptions that anyone can fulfill the program manager role. Global trends will increase the need for collaboration across international and cultural divides. When creating a PMO, it is important to get executive buy-in, recruit from multiple departments to broaden skills, and implement standardized processes while allowing flexibility. Transitioning to program management requires strong business and communication skills in addition to project management skills.