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Dr.Suresh Kumar
Murugesan PhD Biopsychology
About the Presenter
● Dr.Suresh Kumar Murugesan is a passionate Professor,
Researcher and Behavioural Scientist from Madurai, Tamil
Nadu, India
● At present he is Heading the department of Psychology, The
American College, Madurai and Adjunct Professor of School of
Behavioural Sciences and Education at TAU
● He is very keen in new research studies in behavioural
Sciences and open to learn.
● His area of specializations are Psychometry, Positive
Psychotherapy and Cyber Psychology
Yellow
Pond
Disclaimer
● This presentation is prepared
for learning purpose only and
all the images and pictures
used in this presentation are
taken from google image
search.
● Due recognition was given to
all the material collected from
the various sources.
● Any name or reference is
missed kindly bring it to the
notice of the presenter for
inclusion.
● Email -
sureshkumar800@yahoo.com
Thank you
Yellow
Pond
What is
Biopsychology?
• the branch of psychology concerned with
its biological and physiological aspects.
• biopsychology is the study of the brain
and how it influences and develops
behaviour and mental processes.
Yellow
Pond
Biopsychology
Other names of biopsychology are
a.Neuropsychology
b.Biological Psychology
c.Physiological Psychology
d.Clinical Neuropsychology
e.Behavioural Neuroscience
Yellow
Pond
What is Biopsychology?
● A multidisciplinary study of nervous system and the role it plays in
behavior!
● It is a branch of psychology that studies relation between brain and
behavior
Yellow
Pond
What is
Biopsychology?
Biopsychology is merging of several disciplines:
• anatomy and physiology
• Biology and chemistry
• Philosophy
• Psychology: Behavioral, social and cognitive areas, in particular
Yellow
Pond
History of
Biopsychology –
Plato and
Aristotle
• Among the first people to realise that the brain was the organ
of the mind and behaviour were the ancient Greeks.
• For instance, Plato (429–348 BC) proposed that the brain was
the organ of reasoning – although others disagreed, including
his student Aristotle, who believed that the heart served this
function and that the brain merely served to cool blood.
Yellow
Pond
Human Brain -
Animal
Dissection
The ancient Greeks were
aware of the basic shape of
the brain mainly through
animal dissection, and of its
ventricles
Yellow
Pond
Human Brain -
Leonardo da
Vinci
● Throughout most of the ancient world the human body was
considered sacred and autopsies were prohibited.
● The first drawings of the human brain were not undertaken
until the late fifteenth century AD, by Leonardo da Vinci.
Yellow
Pond
Galen
• One of the first writers to propose a theory of brain
function based on the ventricles was Galen (AD 130–
200)
• He was the most important physician of the Roman
imperial period.
Yellow
Pond
Galen -
Anatomical
Discoveries
• Galen made many important anatomical discoveries,
including the cranial nerves that pass between the brain and
the body.
• Galen believed that the heart was the crucial organ of the
body because it contained the vital spirit that gave the spark
of life to the person.
Yellow
Pond
Galen - Heart and Mind
• The vital spirit was also thought to provide the
‘substance’ of the mind, and was transported to a large
group of blood vessels at the base of the brain called
the rete mirabile (‘wonderful net’).
• Here the vital spirit was mixed with air that had been
inhaled through the nose, and transformed into
animated spirit that was stored in the ventricles. When
needed for action, the animated spirit was then
believed to enter nerves resembling hollow tubes, that
passed into the body where it pneumatically moved
muscles to produce behaviour.
Yellow
Pond
Galen - Ventricles
• Galen knew that the brain had four main ventricles (the
first two are now called the lateral ventricles and they
form a symmetrical pair inside the cerebral cortex,
which then feed into the third ventricle located in the
mid-part of the brain, that joins with the fourth
ventricle in the brain stem).
• Others who followed Galen extended his ideas and
gave the ventricles different functions.
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Pond
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Galen and Animal
Dissection
Galen, who had not been allowed to perform human
dissection in Rome, had inferred its human existence by
observing it in cattle and ox on.
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Pond
Nemesius
In the fourth century AD, Nemesius, Bishop
of Emesa, hypothesized that
1. the lateral ventricles were the site of
sensory and mental impressions;
2. the third ventricle the site of reason;
and
3. the fourth ventricle the site of memory.
Yellow
Pond
Augustine
• Augustine of Hippo
(354–430) who was one
of the founding fathers of
the Christian religion.
• With respected spiritual
authority behind it, the
ventricular concept of
brain function became
the most popular theory
in the brain’s written
history and was
accepted as the truth for
nearly 1,500 years.
Yellow
Pond
Vesalius - Anatomical
work
• The concept of rete mirabile began to be
doubted only in the Renaissance when
Vesalius in his great anatomical work De
humani corporis fabrica (1543) showed that
the human brain does not actually contain a
rete mirabile.
Yellow
Pond
René Descartes
René Descartes (1596–1650) was a French
philosopher and mathematician
Yellow
Pond
René Descartes
His famous quote
Cogito; ergo sum (‘I
think, therefore I am’),
which refers to
Descartes’s doubt of all
things except his own
existence, is often seen
as heralding a new age
of reason.
Yellow
Pond
René Descartes
The importance of
Descartes in the
development of psychology
lies largely with his attempt
to resolve the mind–body
problem.
Yellow
Pond
René Descartes He believed, as did Plato, that mind and body are two
entirely different things (a theory known as dualism), with
the body composed of physical matter, and the mind or
soul being non-physical and independent of the material
world.
Yellow
Pond
Pineal gland
A problem with dualism,
however, lies in trying to
explain how the non-material
mind can control the physical
or mechanical workings of the
body.
In his attempt to provide an
answer, Descartes proposed
that mind and body interacted
in the pineal gland.
Yellow
Pond
René Descartes - Pineal
gland
Descartes chose the pineal gland as it was a singular
structure (most other brain areas are bilateral, or ‘paired’) and
because he believed that the soul had to be a unified
indivisible entity.
Yellow
Pond
René Descartes - Pineal
gland
The pineal gland was located close to the third
ventricle and bathed by cerebrospinal fluid.
This provided the pineal gland with a means
by which its minute movements could
influence the animated spirits of the brain.
In other words, the pineal gland provided an
ideal site where the soul could act upon the
body (Mazzolini 1991).
Yellow
Pond
René Descartes
and Royal
Garden
Descartes also realised that a
great deal of behaviour was
mechanical and did not require
mental intervention.
René Descartes
and Royal
Garden
• During a visit to the Royal Gardens in Paris as a young man
that he began to develop the idea.
• The gardens exhibited mechanical statues that moved and
danced whenever they were approached, which was caused
by hydraulic pressure-sensitive plates hidden under the
ground. This led Descartes to speculate that the human body
might work according to similar principles.
René Descartes
He developed the concept of
the automatic reflex which
occurs, for example, when a
limb is quickly moved away
from a hot source such as a
fire.
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Pond
René Descartes
Descartes hypothesised that a sensory
nerve composed of a hollow tube
containing vital spirit conveyed the
message of heat to the ventricles of the
brain; these in turn directed animal spirit
to flow out through the nerves from the
brain, back to the muscles of the affected
limb thereby causing its withdrawal.
Yellow
Pond
René Descartes
• Prior to Descartes, it had generally been
accepted that the soul controlled all the
actions of the human body.
• But Descartes showed that the human body
worked according to mechanical principles –
not unlike the internal workings of a watch –
and did not need a soul to make it operate
once it had been put into motion.
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Pond
René Descartes
Descartes proposed that not only the functions such as
digestion and respiration were reflexive, but also were a
number of mental functions, including sensory
impressions, emotions and memory.
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René Descartes
• He believed that animal had no soul
• Animal were capable of sensory
processing along with emotion and
memory.
• The sensory processes did not need the
involvement of a soul (or mind) in animals
René Descartes
• The one exception was reasoning and pure
thought which Descartes believed was the
exclusive property of the soul and unique to
humans.
• This was a position that allowed his theory
to be in accordance with the religious
teachings of the time.
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René Descartes
(Dualism)
• Descartes’s theory helped lay the
foundations for the modern development of
physiology and psychology.
• His theory was based on a dualist view of
the mind, it helped shift attention towards
the practical problem of how reflexes might
underlie behaviour without fear of
contradicting religious dogma.
Yellow
Pond
René Descartes (Dualism)
• His theory encouraged others to think more
deeply about how the brain worked.
• Descartes provided a great impetus for
experimental research – not least because
some of his ideas could be tested.
Yellow
Pond
René Descartes -
Experiment
• Descartes believed that the nervous system controlling
reflexes was a hydraulic system consisting of hollow
tubes through which animal spirits flowed from the
ventricles to the muscles.
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Pond
René Descartes -
Experiment
• If the idea of Descaes was correct then it followed
that muscles should increase in volume as they
‘swelled’ with spirit during contraction.
• When investigators tested this theory by flexing a
person’s arm in a container of water, however, no
increase in the water level occurred.
Yellow
Pond
René Descartes
- Experiment
• Descartes had paved a way for a scientific
and non-secular approach to understanding
human physiology that included the brain.
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Pond
Luigi Galvani (The
discovery of ‘animal’
electricity)
• In 1791, the idea of animal spirit as the cause of
nervous activity was challenged by the Italian
Luigi Galvani who undertook a series of
experiments on amputated frog legs which
included the exposed ends of their severed
nerves.
Yellow
Pond
Luigi Galvani (The discovery
of ‘animal’ electricity)
• Galvani found that he could induce a leg to twitch in a
number of ways – as indeed shown in one famous case
where, during a thunderstorm, he connected a nerve
stump to a long metallic wire that pointed to the sky and
obtained strong muscular contractions in the detached
leg (Galvani was obviously unaware of the great
dangers of such a demonstration).
Yellow
Pond
Luigi Galvani (The discovery
of ‘animal’ electricity)
• He found that similar movements were produced
when he suspended a frog’s leg between two
different metals.
• Although he did not know it at the time, Galvani
had shown that when dissimilar metals make
contact through a salt solution an electrical current
is produced.
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Pond
Luigi Galvani (The
discovery of ‘animal’
electricity)
• The first demonstration of the battery later formally invented
by Volta in 1800. These discoveries led Galvani to conclude
that nerves are capable of conducting electricity and that their
‘invisible spirit’ must be electrical in nature.
Yellow
Pond
Luigi Galvani (The discovery
of ‘animal’ electricity)
• Nerve conduct electricity was finally proved
beyond reasonable doubt in 1820 when the
German Johann Schweigger invented the
galvanometer (named in honour of Galvani)
Yellow
Pond
Luigi Galvani (The
discovery of ‘animal’
electricity)
• It measured the strength and direction of an electrical current.
Indeed, this invention soon showed that nervous tissue
contained intrinsic electrical energy.
Yellow
Pond
Luigi Galvani (The
discovery of ‘animal’
electricity)
• The twitching frogs’ legs marked the end to
hydraulic theories of nervous action and the
start of a new chapter in understanding how
nerve cells work (Piccolino 1997).
Yellow
Pond
Johannes Müller (Speed
of nerve impulse is of light
speed)
• One question that fascinated
neurophysiologists during this time was the
speed of the nervous impulse that flowed
down the fibre (axon).
• Although the galvanometer could detect
electrical activity, the nerve impulse
appeared to be instantaneous and too fast
to be measured.
Yellow
Pond
Johannes Müller
(Speed of nerve
impulse is of light
speed)
• The famous physiologist Johannes Müller wrote
somewhat despairingly in 1833 that the speed of the
nerve impulse was comparable to the speed of light and
would never be accurately estimated.
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Pond
Hermann von Helmholtz
(Speed of nerve impulse= 98
km/hr)
• However, Müller was soon proved wrong by the
work of Hermann von Helmholtz who managed,
in 1850, to extract long motor nerves (some 50–60
mm in length) that were still attached to muscles
taken from frogs’ legs.
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Pond
Hermann von Helmholtz
(Speed of nerve
impulse= 98 km/hr)
• Helmholtz recorded the delay between the
onset of electrical stimulation and the resulting
muscle twitch, and calculated the speed of the
impulse to be about 90 feet per second, which
translates to around 98 kilometres per hour.
Yellow
Pond
Hermann von Helmholtz
(Speed of nerve impulse= 98
km/hr)
• We now know that Helmholtz was fairly accurate in his
estimation. Moreover, while the nerve impulse was fast,
it was not comparable with the speed of light.
• In fact, neurophysiologists have now established that
speed of nerve conduction varies depending on the
type of axon
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Pond
Hermann von
Helmholtz (Speed
of nerve impulse=
98 km/hr)
• the impulse being quicker in
large-diameter myelinated
axons (for example, the
fastest neuron can conduct
action potentials at a speed
of 120 metres per second, or
432 kilometres per hour),
and slowest in small-
diameter unmyelinated
axons (at 35 metres per
second).
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Pond
Camillo Golgi
(Stain - Silver
Nitrate)
In 1875, a major breakthrough
occurred when the Italian
anatomist Camillo Golgi (1843–
1926) discovered a new stain
that allowed individual nerve
cells to be observed.
Yellow
Pond
Camillo Golgi (Stain -
Silver Nitrate)
• He found that when nervous tissue was exposed to
silver nitrate, the nerve cells would turn black.
• This caused them to stand out in bold relief so they
could clearly be seen under a microscope. But, more
importantly, Golgi’s technique only stained around 2
percent of the cells in any given slice of nervous tissue.
• This was a great advance as it made individual
neurons, and all their various components such as
dendrites and axons, much more clearly observable
Yellow
Pond
Ramón Y Cajal
• Ramón y Cajal’s most important contribution
to neuroanatomy was his discovery that
nerve cells were separate and individual
units.
• Previously, it had been believed that nerve
cells were joined together in a network of
tubes which allowed the direct passage of
information from cell to cell.
Yellow
Pond
Thank you
Yellow
Pond

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Introduction to biopsychology 2.0

  • 2. About the Presenter ● Dr.Suresh Kumar Murugesan is a passionate Professor, Researcher and Behavioural Scientist from Madurai, Tamil Nadu, India ● At present he is Heading the department of Psychology, The American College, Madurai and Adjunct Professor of School of Behavioural Sciences and Education at TAU ● He is very keen in new research studies in behavioural Sciences and open to learn. ● His area of specializations are Psychometry, Positive Psychotherapy and Cyber Psychology Yellow Pond
  • 3. Disclaimer ● This presentation is prepared for learning purpose only and all the images and pictures used in this presentation are taken from google image search. ● Due recognition was given to all the material collected from the various sources. ● Any name or reference is missed kindly bring it to the notice of the presenter for inclusion. ● Email - sureshkumar800@yahoo.com Thank you Yellow Pond
  • 4. What is Biopsychology? • the branch of psychology concerned with its biological and physiological aspects. • biopsychology is the study of the brain and how it influences and develops behaviour and mental processes. Yellow Pond
  • 5. Biopsychology Other names of biopsychology are a.Neuropsychology b.Biological Psychology c.Physiological Psychology d.Clinical Neuropsychology e.Behavioural Neuroscience Yellow Pond
  • 6. What is Biopsychology? ● A multidisciplinary study of nervous system and the role it plays in behavior! ● It is a branch of psychology that studies relation between brain and behavior Yellow Pond
  • 7. What is Biopsychology? Biopsychology is merging of several disciplines: • anatomy and physiology • Biology and chemistry • Philosophy • Psychology: Behavioral, social and cognitive areas, in particular Yellow Pond
  • 8. History of Biopsychology – Plato and Aristotle • Among the first people to realise that the brain was the organ of the mind and behaviour were the ancient Greeks. • For instance, Plato (429–348 BC) proposed that the brain was the organ of reasoning – although others disagreed, including his student Aristotle, who believed that the heart served this function and that the brain merely served to cool blood. Yellow Pond
  • 9. Human Brain - Animal Dissection The ancient Greeks were aware of the basic shape of the brain mainly through animal dissection, and of its ventricles Yellow Pond
  • 10. Human Brain - Leonardo da Vinci ● Throughout most of the ancient world the human body was considered sacred and autopsies were prohibited. ● The first drawings of the human brain were not undertaken until the late fifteenth century AD, by Leonardo da Vinci. Yellow Pond
  • 11. Galen • One of the first writers to propose a theory of brain function based on the ventricles was Galen (AD 130– 200) • He was the most important physician of the Roman imperial period. Yellow Pond
  • 12. Galen - Anatomical Discoveries • Galen made many important anatomical discoveries, including the cranial nerves that pass between the brain and the body. • Galen believed that the heart was the crucial organ of the body because it contained the vital spirit that gave the spark of life to the person. Yellow Pond
  • 13. Galen - Heart and Mind • The vital spirit was also thought to provide the ‘substance’ of the mind, and was transported to a large group of blood vessels at the base of the brain called the rete mirabile (‘wonderful net’). • Here the vital spirit was mixed with air that had been inhaled through the nose, and transformed into animated spirit that was stored in the ventricles. When needed for action, the animated spirit was then believed to enter nerves resembling hollow tubes, that passed into the body where it pneumatically moved muscles to produce behaviour. Yellow Pond
  • 14. Galen - Ventricles • Galen knew that the brain had four main ventricles (the first two are now called the lateral ventricles and they form a symmetrical pair inside the cerebral cortex, which then feed into the third ventricle located in the mid-part of the brain, that joins with the fourth ventricle in the brain stem). • Others who followed Galen extended his ideas and gave the ventricles different functions. Yellow Pond
  • 16. Galen and Animal Dissection Galen, who had not been allowed to perform human dissection in Rome, had inferred its human existence by observing it in cattle and ox on. Yellow Pond
  • 17. Nemesius In the fourth century AD, Nemesius, Bishop of Emesa, hypothesized that 1. the lateral ventricles were the site of sensory and mental impressions; 2. the third ventricle the site of reason; and 3. the fourth ventricle the site of memory. Yellow Pond
  • 18. Augustine • Augustine of Hippo (354–430) who was one of the founding fathers of the Christian religion. • With respected spiritual authority behind it, the ventricular concept of brain function became the most popular theory in the brain’s written history and was accepted as the truth for nearly 1,500 years. Yellow Pond
  • 19. Vesalius - Anatomical work • The concept of rete mirabile began to be doubted only in the Renaissance when Vesalius in his great anatomical work De humani corporis fabrica (1543) showed that the human brain does not actually contain a rete mirabile. Yellow Pond
  • 20. René Descartes René Descartes (1596–1650) was a French philosopher and mathematician Yellow Pond
  • 21. René Descartes His famous quote Cogito; ergo sum (‘I think, therefore I am’), which refers to Descartes’s doubt of all things except his own existence, is often seen as heralding a new age of reason. Yellow Pond
  • 22. René Descartes The importance of Descartes in the development of psychology lies largely with his attempt to resolve the mind–body problem. Yellow Pond
  • 23. René Descartes He believed, as did Plato, that mind and body are two entirely different things (a theory known as dualism), with the body composed of physical matter, and the mind or soul being non-physical and independent of the material world. Yellow Pond
  • 24. Pineal gland A problem with dualism, however, lies in trying to explain how the non-material mind can control the physical or mechanical workings of the body. In his attempt to provide an answer, Descartes proposed that mind and body interacted in the pineal gland. Yellow Pond
  • 25. René Descartes - Pineal gland Descartes chose the pineal gland as it was a singular structure (most other brain areas are bilateral, or ‘paired’) and because he believed that the soul had to be a unified indivisible entity. Yellow Pond
  • 26. René Descartes - Pineal gland The pineal gland was located close to the third ventricle and bathed by cerebrospinal fluid. This provided the pineal gland with a means by which its minute movements could influence the animated spirits of the brain. In other words, the pineal gland provided an ideal site where the soul could act upon the body (Mazzolini 1991). Yellow Pond
  • 27. René Descartes and Royal Garden Descartes also realised that a great deal of behaviour was mechanical and did not require mental intervention.
  • 28. René Descartes and Royal Garden • During a visit to the Royal Gardens in Paris as a young man that he began to develop the idea. • The gardens exhibited mechanical statues that moved and danced whenever they were approached, which was caused by hydraulic pressure-sensitive plates hidden under the ground. This led Descartes to speculate that the human body might work according to similar principles.
  • 29. René Descartes He developed the concept of the automatic reflex which occurs, for example, when a limb is quickly moved away from a hot source such as a fire. Yellow Pond
  • 30. René Descartes Descartes hypothesised that a sensory nerve composed of a hollow tube containing vital spirit conveyed the message of heat to the ventricles of the brain; these in turn directed animal spirit to flow out through the nerves from the brain, back to the muscles of the affected limb thereby causing its withdrawal. Yellow Pond
  • 31. René Descartes • Prior to Descartes, it had generally been accepted that the soul controlled all the actions of the human body. • But Descartes showed that the human body worked according to mechanical principles – not unlike the internal workings of a watch – and did not need a soul to make it operate once it had been put into motion. Yellow Pond
  • 32. René Descartes Descartes proposed that not only the functions such as digestion and respiration were reflexive, but also were a number of mental functions, including sensory impressions, emotions and memory. Yellow Pond
  • 33. René Descartes • He believed that animal had no soul • Animal were capable of sensory processing along with emotion and memory. • The sensory processes did not need the involvement of a soul (or mind) in animals
  • 34. René Descartes • The one exception was reasoning and pure thought which Descartes believed was the exclusive property of the soul and unique to humans. • This was a position that allowed his theory to be in accordance with the religious teachings of the time. Yellow Pond
  • 35. René Descartes (Dualism) • Descartes’s theory helped lay the foundations for the modern development of physiology and psychology. • His theory was based on a dualist view of the mind, it helped shift attention towards the practical problem of how reflexes might underlie behaviour without fear of contradicting religious dogma. Yellow Pond
  • 36. René Descartes (Dualism) • His theory encouraged others to think more deeply about how the brain worked. • Descartes provided a great impetus for experimental research – not least because some of his ideas could be tested. Yellow Pond
  • 37. René Descartes - Experiment • Descartes believed that the nervous system controlling reflexes was a hydraulic system consisting of hollow tubes through which animal spirits flowed from the ventricles to the muscles. Yellow Pond
  • 38. René Descartes - Experiment • If the idea of Descaes was correct then it followed that muscles should increase in volume as they ‘swelled’ with spirit during contraction. • When investigators tested this theory by flexing a person’s arm in a container of water, however, no increase in the water level occurred. Yellow Pond
  • 39. René Descartes - Experiment • Descartes had paved a way for a scientific and non-secular approach to understanding human physiology that included the brain. Yellow Pond
  • 40. Luigi Galvani (The discovery of ‘animal’ electricity) • In 1791, the idea of animal spirit as the cause of nervous activity was challenged by the Italian Luigi Galvani who undertook a series of experiments on amputated frog legs which included the exposed ends of their severed nerves. Yellow Pond
  • 41. Luigi Galvani (The discovery of ‘animal’ electricity) • Galvani found that he could induce a leg to twitch in a number of ways – as indeed shown in one famous case where, during a thunderstorm, he connected a nerve stump to a long metallic wire that pointed to the sky and obtained strong muscular contractions in the detached leg (Galvani was obviously unaware of the great dangers of such a demonstration). Yellow Pond
  • 42. Luigi Galvani (The discovery of ‘animal’ electricity) • He found that similar movements were produced when he suspended a frog’s leg between two different metals. • Although he did not know it at the time, Galvani had shown that when dissimilar metals make contact through a salt solution an electrical current is produced. Yellow Pond
  • 43. Luigi Galvani (The discovery of ‘animal’ electricity) • The first demonstration of the battery later formally invented by Volta in 1800. These discoveries led Galvani to conclude that nerves are capable of conducting electricity and that their ‘invisible spirit’ must be electrical in nature. Yellow Pond
  • 44. Luigi Galvani (The discovery of ‘animal’ electricity) • Nerve conduct electricity was finally proved beyond reasonable doubt in 1820 when the German Johann Schweigger invented the galvanometer (named in honour of Galvani) Yellow Pond
  • 45. Luigi Galvani (The discovery of ‘animal’ electricity) • It measured the strength and direction of an electrical current. Indeed, this invention soon showed that nervous tissue contained intrinsic electrical energy. Yellow Pond
  • 46. Luigi Galvani (The discovery of ‘animal’ electricity) • The twitching frogs’ legs marked the end to hydraulic theories of nervous action and the start of a new chapter in understanding how nerve cells work (Piccolino 1997). Yellow Pond
  • 47. Johannes Müller (Speed of nerve impulse is of light speed) • One question that fascinated neurophysiologists during this time was the speed of the nervous impulse that flowed down the fibre (axon). • Although the galvanometer could detect electrical activity, the nerve impulse appeared to be instantaneous and too fast to be measured. Yellow Pond
  • 48. Johannes Müller (Speed of nerve impulse is of light speed) • The famous physiologist Johannes Müller wrote somewhat despairingly in 1833 that the speed of the nerve impulse was comparable to the speed of light and would never be accurately estimated. Yellow Pond
  • 49. Hermann von Helmholtz (Speed of nerve impulse= 98 km/hr) • However, Müller was soon proved wrong by the work of Hermann von Helmholtz who managed, in 1850, to extract long motor nerves (some 50–60 mm in length) that were still attached to muscles taken from frogs’ legs. Yellow Pond
  • 50. Hermann von Helmholtz (Speed of nerve impulse= 98 km/hr) • Helmholtz recorded the delay between the onset of electrical stimulation and the resulting muscle twitch, and calculated the speed of the impulse to be about 90 feet per second, which translates to around 98 kilometres per hour. Yellow Pond
  • 51. Hermann von Helmholtz (Speed of nerve impulse= 98 km/hr) • We now know that Helmholtz was fairly accurate in his estimation. Moreover, while the nerve impulse was fast, it was not comparable with the speed of light. • In fact, neurophysiologists have now established that speed of nerve conduction varies depending on the type of axon Yellow Pond
  • 52. Hermann von Helmholtz (Speed of nerve impulse= 98 km/hr) • the impulse being quicker in large-diameter myelinated axons (for example, the fastest neuron can conduct action potentials at a speed of 120 metres per second, or 432 kilometres per hour), and slowest in small- diameter unmyelinated axons (at 35 metres per second). Yellow Pond
  • 53. Camillo Golgi (Stain - Silver Nitrate) In 1875, a major breakthrough occurred when the Italian anatomist Camillo Golgi (1843– 1926) discovered a new stain that allowed individual nerve cells to be observed. Yellow Pond
  • 54. Camillo Golgi (Stain - Silver Nitrate) • He found that when nervous tissue was exposed to silver nitrate, the nerve cells would turn black. • This caused them to stand out in bold relief so they could clearly be seen under a microscope. But, more importantly, Golgi’s technique only stained around 2 percent of the cells in any given slice of nervous tissue. • This was a great advance as it made individual neurons, and all their various components such as dendrites and axons, much more clearly observable Yellow Pond
  • 55. Ramón Y Cajal • Ramón y Cajal’s most important contribution to neuroanatomy was his discovery that nerve cells were separate and individual units. • Previously, it had been believed that nerve cells were joined together in a network of tubes which allowed the direct passage of information from cell to cell. Yellow Pond