This document describes a laboratory automation system that was designed and implemented using a Siemens PLC S7-200. The system uses various sensors like a temperature sensor and LDR sensor that are interfaced with the PLC. The temperature sensor monitors temperature and controls the speed of a fan depending on the temperature. The LDR sensor controls the illumination level of lights. Motors are also used to control curtain opening and closing. The real-time system developed is effective, efficient and allows remote control of laboratory appliances to save energy.