This document analyzes the effect of soil-structure interaction on the response of a three-story building frame supported by a piled-raft foundation. A finite element model is developed to model the frame, slab, beams, columns, piles, raft, and soil. Parametric studies are conducted to evaluate the effect of raft thickness and pile diameter on frame displacements. The key findings are that considering soil-structure interaction increases frame displacements compared to assuming a fixed base, and displacements decrease with increasing pile diameter and raft thickness due to improved soil resistance. Nonlinear soil behavior further reduces displacements compared to linear analysis.