This document discusses strategies for maintaining very large MySQL tables that have grown too big. It recommends creating a new database server with different configuration settings like InnoDB file per table to reduce size, using tools like MySQLTuner and tuning-primer to analyze settings, archiving old historical data with ptArchiver to reduce table sizes, and considering partitioning or changing the MySQL version. Monitoring tools like InnoDB status, global status, cacti and innotop are recommended to analyze server performance.