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LYMPHATIC
SYSTEM
By-
Dr Garima Sehgal
Lecturer
Department of Anatomy
KGMU
LYMP
H
 What is lymph ?
Tissue fluid (interstitial fluid)
that enters the lymphatic vessels
FORMATION AND
TRANSPORT OF TISSUE
FLUID
Essentially a
drainage system
accessory to
venous system
larger particles that
escape into tissue fluid
can only be removed
via lymphatic system
LYMPHATIC SYSTE
Functions of the Lymphatic
System
24-
5 Reabsorbs excess interstitial fluid:
 returns it to the venous circulation
 maintain blood volume levels
 prevent interstitial fluid levels from rising out of
control.
 Transport dietary lipids:
 transported through lacteals
 drain into larger lymphatic vessels
 eventually into the bloodstream.
 lymphocyte development, and the immune
Components of the Lymphatic
System24-
6  Lymph
 Lymphatic Vessels
 Lymphatic Capillaries
 Lymphatic Vessels
 Lymphatic Trunks
 Lymphatic Ducts
 Lymphatic Organs
 Thymus
 Lymph Nodes
 Spleen
 Tonsils
 Lymphatic cells
Lymph Vessels
 Lymphatic capillaries –
 Lymphatic collecting vessels
 Lymphatic trunks –
 Lymphatic ducts –
Lymphatic system (function of lymphatic systems)
Lymphatic Capillaries
24-
9
Features of structure:
 Blind end
 Single layer of overlapping
endothelial cells
 More permeable than that
of blood capillary
 Absent from avascular
structures, brain, spinal
cord splenic pulp and bone
marrow
Lymphatic Capillaries –
Lacteals
24-
10
 The small intestine contains special
types of lymphatic capillaries called
lacteals.
 Lacteals pick up not only interstitial
fluid, but also dietary lipids and
lipid-soluble vitamins.
 The lymph of this area has a milky
color due to the lipid and is also
Lymphatic Vessels
24-
11
Features of
structure
Three layered wall
but thinner than
vein,
More numerous
valves than in vein
Interposed by
lymph nodes at
intervals

LYMPH TRUNKS
 right and left jugular
trunks
 right and left subclavian
trunks
 right and left
bronchomediastinal trunks
LYMPHATIC
DUCTS
24-
13
Right lymphatic duct
 Formed by union of
right jugular,
subclavian, and
bronchomediastinal
trunks
 Ends by entering the
right venous angle
Thoracic duct
 Begins in front of L1 as
a dilated sac, the
cisterna chyli,
 formed by left and
right lumbar trunks
and intestinal trunk
 Enter thoracic cavity &
ascends
 Travels upward,
LYMPHATIC
DUCTS
15
THORACIC DUCT…..
 At the root of the
neck, it turns
laterally
 arches forwards and
descends to enter the
left venous angle
 before termination,
it receives the left
jugular, Subclavian
and broncho-
DRAINAGE PATTERN
THORACIC DUCT -
Drains lymph from
lower limbs, pelvic
cavity, abdominal
cavity, left side of
thorax, and left side of
RIGHT LYMPHATIC
DUCT -Receives lymph
from right half of head,
neck, thorax and right
upper limb, right lung,
right side of heart, right
surface of liver
Lymphatic Cells
24-
17
 Also called lymphoid cells.
 Located in both the lymphatic system
and the cardiovascular system.
 Work together to elicit an immune
response.
 Types of lymphatic cells are:
 macrophages
 epithelial cells
 dendritic cells
 lymphocytes
LYMPHATIC ORGANS
Primary organs
 Red bone marrow
 Thymus gland
Secondary organs
 Lymph nodes
 Lymph nodules
 Spleen
Lymph
Nodes24-
19 Small, round or oval
 located along the
pathways of lymph
vessels.
 length from 1 - 25
millimeters
 Typically found in
clusters
 receive lymph from
many body regions.
 Lymph nodes are also
Lymph node
Features
 Bean-shaped bodies
 With afferent vessels
(entering at the
periphery) and efferent
lymph vessels(emerging at
the hilus)
 Arranged in groups, along
the blood vessels or the
flexural side of the joint
 Divided into superficial
21
 Regional Lymph Node is the
lymph node where the lymph of the
organ or part of the body drainge to
firstly
Sentinel Lymph Node(in clinic)
Regional Lymph drainage
22
Spleen
Location
Left epigastric region
between 9th
-11th
rib
in line of 10th
rib
 Largest lymphatic organ in the
body.
 Can vary considerably in size
and weight
Function
23
THYMUS
Features
 Consists of two
elongated lobes
 Is a large organ in
the fetus
 Occupies the
thoracic cavity
behind the sternum
 Secrete
lymphopoietin
Lymphatic Nodules
24-
24 Oval clusters of lymphatic cells with some
extracellular matrix that are not surrounded
by a connective tissue capsule.
 Filter and attack antigens.
 In some areas of the body, many lymphatic nodules
group together to form larger structures.
 mucosa-associated lymphatic tissue (MALT) or
tonsils
 very prominent in the mucosa of the small intestine,
primarily in the ileum
Peyer patches

Lymphatic system (function of lymphatic systems)
Tonsils
24-
26 clusters of lymphatic cells and
extracellular matrix not completely
surrounded by a connective tissue
capsule.
 Consist of multiple germinal centers and
crypts
 Several groups of tonsils form a
protective ring around the pharynx.
 pharyngeal tonsils (or adenoids) in
nasopharynx
 palatine tonsils in oral cavity
MALT (Mucosa Associated
Lymphoid Tissue)27
APPLIE
D
ANATOM
Y
LYMPHANGITIS
  Inflammation of the
lymph vessels
 Commonest cause
bacteria called
streptococcus
pyogenes(most
common).
 Lymph vessels appear
as red streaks through
FILARIASIS
LYMPHEDEMA
 Occurs due to
accumulation of
lymphatic fluid in
the interstitial
tissue
 Sometimes can be
appreciated after
wearing tight
clothing or
LYMPHADENOPATHY
 Means a disease
of the lymph
nodes
 Lymph nodes
become swollen/
enlarged and may
be painful to
touch
LYMPHOMAS
 Cancers
originating either
from the
lymphocytes in
the lymph nodes
or the lymphatic
tissue in organs
 Risk factors --
HIV,
HEPATITIS,
TONSILLITIS
 Infection of the
pharyngeal tonsils
 Tonsils are
swollen,
 Fever and pain
during swallowing
usually present
 Treatment –
surgical removal
of tonsils
SPLENOMEGALY
 Enlarged
Spleen
 Various
causes
LET’S REVISE
SOME
IMPORTANT
FACTS
Name the structures labelled
A-E.
QUESTION. 1
 I am a part of lymphatic system and
protect the body by clearing worn out red
cells and foreign bodies from the blood
stream. Who am I?
A. Thymus
B. Palatine
Tonsil
C. Spleen
QUESTION. 2
Which is the correct statement about the
Lymphatic system?
A. It Reabsorbs excess interstitial fluid and
returns it to the venous circulation.
B. Transports dietary lipids through
lacteals.
C. Helps in lymphocyte development, and the
immune response.
QUESTION. 3
 Which disease caused by
mosquito bite blocks the
lymphatic drainage causing
huge swelling of body parts
(commonly lower limb)
A. Malaria
B. Filaria
C. Dengue
D. Yellow fever
QUESTION. 4
 Which of these is a primary
lymphoid organ ?
A. Lymph Node
B. Spleen
C. Tonsil
D. Bone Marrow
QUESTION. 5

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Lymphatic system (function of lymphatic systems)

  • 2. LYMP H  What is lymph ? Tissue fluid (interstitial fluid) that enters the lymphatic vessels
  • 4. Essentially a drainage system accessory to venous system larger particles that escape into tissue fluid can only be removed via lymphatic system LYMPHATIC SYSTE
  • 5. Functions of the Lymphatic System 24- 5 Reabsorbs excess interstitial fluid:  returns it to the venous circulation  maintain blood volume levels  prevent interstitial fluid levels from rising out of control.  Transport dietary lipids:  transported through lacteals  drain into larger lymphatic vessels  eventually into the bloodstream.  lymphocyte development, and the immune
  • 6. Components of the Lymphatic System24- 6  Lymph  Lymphatic Vessels  Lymphatic Capillaries  Lymphatic Vessels  Lymphatic Trunks  Lymphatic Ducts  Lymphatic Organs  Thymus  Lymph Nodes  Spleen  Tonsils  Lymphatic cells
  • 7. Lymph Vessels  Lymphatic capillaries –  Lymphatic collecting vessels  Lymphatic trunks –  Lymphatic ducts –
  • 9. Lymphatic Capillaries 24- 9 Features of structure:  Blind end  Single layer of overlapping endothelial cells  More permeable than that of blood capillary  Absent from avascular structures, brain, spinal cord splenic pulp and bone marrow
  • 10. Lymphatic Capillaries – Lacteals 24- 10  The small intestine contains special types of lymphatic capillaries called lacteals.  Lacteals pick up not only interstitial fluid, but also dietary lipids and lipid-soluble vitamins.  The lymph of this area has a milky color due to the lipid and is also
  • 11. Lymphatic Vessels 24- 11 Features of structure Three layered wall but thinner than vein, More numerous valves than in vein Interposed by lymph nodes at intervals 
  • 12. LYMPH TRUNKS  right and left jugular trunks  right and left subclavian trunks  right and left bronchomediastinal trunks
  • 13. LYMPHATIC DUCTS 24- 13 Right lymphatic duct  Formed by union of right jugular, subclavian, and bronchomediastinal trunks  Ends by entering the right venous angle
  • 14. Thoracic duct  Begins in front of L1 as a dilated sac, the cisterna chyli,  formed by left and right lumbar trunks and intestinal trunk  Enter thoracic cavity & ascends  Travels upward, LYMPHATIC DUCTS
  • 15. 15 THORACIC DUCT…..  At the root of the neck, it turns laterally  arches forwards and descends to enter the left venous angle  before termination, it receives the left jugular, Subclavian and broncho-
  • 16. DRAINAGE PATTERN THORACIC DUCT - Drains lymph from lower limbs, pelvic cavity, abdominal cavity, left side of thorax, and left side of RIGHT LYMPHATIC DUCT -Receives lymph from right half of head, neck, thorax and right upper limb, right lung, right side of heart, right surface of liver
  • 17. Lymphatic Cells 24- 17  Also called lymphoid cells.  Located in both the lymphatic system and the cardiovascular system.  Work together to elicit an immune response.  Types of lymphatic cells are:  macrophages  epithelial cells  dendritic cells  lymphocytes
  • 18. LYMPHATIC ORGANS Primary organs  Red bone marrow  Thymus gland Secondary organs  Lymph nodes  Lymph nodules  Spleen
  • 19. Lymph Nodes24- 19 Small, round or oval  located along the pathways of lymph vessels.  length from 1 - 25 millimeters  Typically found in clusters  receive lymph from many body regions.  Lymph nodes are also
  • 20. Lymph node Features  Bean-shaped bodies  With afferent vessels (entering at the periphery) and efferent lymph vessels(emerging at the hilus)  Arranged in groups, along the blood vessels or the flexural side of the joint  Divided into superficial
  • 21. 21  Regional Lymph Node is the lymph node where the lymph of the organ or part of the body drainge to firstly Sentinel Lymph Node(in clinic) Regional Lymph drainage
  • 22. 22 Spleen Location Left epigastric region between 9th -11th rib in line of 10th rib  Largest lymphatic organ in the body.  Can vary considerably in size and weight Function
  • 23. 23 THYMUS Features  Consists of two elongated lobes  Is a large organ in the fetus  Occupies the thoracic cavity behind the sternum  Secrete lymphopoietin
  • 24. Lymphatic Nodules 24- 24 Oval clusters of lymphatic cells with some extracellular matrix that are not surrounded by a connective tissue capsule.  Filter and attack antigens.  In some areas of the body, many lymphatic nodules group together to form larger structures.  mucosa-associated lymphatic tissue (MALT) or tonsils  very prominent in the mucosa of the small intestine, primarily in the ileum Peyer patches 
  • 26. Tonsils 24- 26 clusters of lymphatic cells and extracellular matrix not completely surrounded by a connective tissue capsule.  Consist of multiple germinal centers and crypts  Several groups of tonsils form a protective ring around the pharynx.  pharyngeal tonsils (or adenoids) in nasopharynx  palatine tonsils in oral cavity
  • 29. LYMPHANGITIS   Inflammation of the lymph vessels  Commonest cause bacteria called streptococcus pyogenes(most common).  Lymph vessels appear as red streaks through
  • 31. LYMPHEDEMA  Occurs due to accumulation of lymphatic fluid in the interstitial tissue  Sometimes can be appreciated after wearing tight clothing or
  • 32. LYMPHADENOPATHY  Means a disease of the lymph nodes  Lymph nodes become swollen/ enlarged and may be painful to touch
  • 33. LYMPHOMAS  Cancers originating either from the lymphocytes in the lymph nodes or the lymphatic tissue in organs  Risk factors -- HIV, HEPATITIS,
  • 34. TONSILLITIS  Infection of the pharyngeal tonsils  Tonsils are swollen,  Fever and pain during swallowing usually present  Treatment – surgical removal of tonsils
  • 37. Name the structures labelled A-E. QUESTION. 1
  • 38.  I am a part of lymphatic system and protect the body by clearing worn out red cells and foreign bodies from the blood stream. Who am I? A. Thymus B. Palatine Tonsil C. Spleen QUESTION. 2
  • 39. Which is the correct statement about the Lymphatic system? A. It Reabsorbs excess interstitial fluid and returns it to the venous circulation. B. Transports dietary lipids through lacteals. C. Helps in lymphocyte development, and the immune response. QUESTION. 3
  • 40.  Which disease caused by mosquito bite blocks the lymphatic drainage causing huge swelling of body parts (commonly lower limb) A. Malaria B. Filaria C. Dengue D. Yellow fever QUESTION. 4
  • 41.  Which of these is a primary lymphoid organ ? A. Lymph Node B. Spleen C. Tonsil D. Bone Marrow QUESTION. 5