Methods of life extension currently availabel
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This document provides an overview of currently available methods for life extension organized into the following categories: lifestyle changes, social life, ecology, motivation, country of residence, risk reduction, health checks, nutrition, mobility, supplements, sleep, controlling health parameters, hormone therapy, hormesis, medications, medical insurance, brain health, regeneration, cryonics, and maintaining motivation. The document outlines specific actions individuals can take within each category to potentially extend their lifespan based on current scientific research and understanding.
Methods of life extension currently availabel
- 1. A Map of Currently Available Life Extension Methods This is not medical advice, always consult professionals about your own individual case MedicineLifestyle Slowing the aging process Step 2 Self Organization Step 3 Lowering immediate risks Addictions control 1. Smoking Switch to electronic cigarettes 2. Alcohol Switch to beverages weak in alcohol or red wine 3. Overeating Dietary diversity, reducing food amount, eat only in beautiful places 4. Drugs Do not inject opiates Switch to milder options if possible Find safe and useful pleasures Social 1. People with pets live longer 2. Be part of big and caring fam- ily or social group; don’t live alone. (Men with wives live long- er) 3. Work and demand: retired people die faster: do not retire or find new occupations 4. Creative occupation: amateur artists live longer 5. Have a higher income 6. Live in places with higher life expectancy (cities, villages, re- gions), usually indicators of a good ecology, a safe neigh- bourhood and high quality medi- cine Ecology Clean air and water Clean food Clean place; parks Step 1 Motivation Good Mood Depression is related to a low standard of living, and prevents the implementation of any actions for life extension Treatment of depression 1. Professional -- antidepressants and psychotherapy 2. Vitamins B, C, K2, D 3. Bright light (over 10,000 lumens) 4. New drugs and nootropics Useful Entertainment 1. Socialization (daily communication with nice people) 2. A variety of activities, entertainment 3. Increasing intelligence 4. Creative work 5. Travel 6. Improving your social status Avoiding stress 1. Do not deal with toxic people 2. Treat psychosomatics disorders 3. Avoid anger, resentment and depression 4. Mindfulness, awareness 5. Supplements to combat stress Country of Residence Cons of Moving 1. Some variations in life expec- tancy linked to genes 2. Moving is stressful 3. Some countries are very ex- pensive (Monaco has the highest life expectancy) 4. Problems of legalization and methods of insurance Criteria for selecting the country 1. The price (cheapness) and quality of medicine (Europe, Ko- rea, Canada) 2. Safety and friendliness of the population 3. Access to the latest technolo- gies (USA), to cryonics 4. Good weather and diet (Medi- terranean) Risk Reduction Injuries 1. Wear a seat belt behind the wheel, do not drive faster than 80 mph, do not drive drunk, do not drive onto the oncoming traffic lane, do not order expensive taxis. Do not go to dangerous places with bad roads. Buy safe car - heavy, new, with autopilot (some cars like Dodge caravan are 1000 times safer than worst cars). Light-returning closes. 2. Fire protection: alarm, metal door 3. Caution on the water 4. Have professionals do repairs in electricity and other things Infections 1. Protection during sex (AIDS) 2. Hygiene: washing hands, teeth 3. Vaccines (including anti-cancer): in time vaccination Social Life 1. Comply with rules and laws 2. Increase the level of control over your behaviour, calculating its effects 3. Avoid the risk of violence and conflict Find and stop most dangerous your illnesses Control chronic ailments 1. Hypertension 2. Heart diseases 3. Diabetes 4. Chronic inflammation 5. Infections 6. No self-treatment Find most probable course of your early death and prevent it Regular Check-Up 1. By doctor’s appointments 2. Excessive testing can be harmful Problems: fear, time, falseness ? 3. Need a regular full medical examination 4. Includes chest X-rays, CT scans, heart, colonoscopy, stomach, blood 5. Control blood level of consumed supplements Personal Medicine 1. 23andMe analysis – know your genetic characteristics 2. Electronic health card 3. A blood test for a set of parameters 4. Personal doctor Nutrition Principles 1. Adhere to scientific advice approved by the FDA 2. Consume high-quality, fresh food 3. Balance and regiment 4. Listen to the needs of your body 5. Don’t change diet extremely 6. Organization solution: health food provider Diets 1. Calorie restriction – not proven in humans, but it is not necessary to overeat 2. Useful products: oily fish, fruit (blueberries, berries, apples, but not very sweet ones), vegetables (spinach, broccoli, tomatoes, herbs, but not potatoes) 3. Harmful products: sugar, meat, fat, salt, fried food, spicy food. De- pends on the type of person 4. Nutritious food – you need more than 600 essential substances 5. The Mediterranean diet 6. Intermittent fasting Mobility 1. Walking and running 2. Less sitting 3. Well-chosen workouts 4. Dance 5. Avoiding injuries and trauma-causing sport 6. Personal trainer 7. Joyful social games Supplements that are safe and good for life extension based on some studies Principles 1. Control of the blood concentration and side effects 2. Control based on genotype and consultation with independent special- ist 3. Systematic approach and analysis of parameters (weight, mood, pres- sure) 4. Cycling of supplements 5. Add one by one 6. Proven/approved manufacturers Substances 1. Minerals: lithium; selenium (increased life expectancy in Finland) 2. Vitamins: D, K2, B5, B9, B12 3. Green Tea and Caffeine 4. Q-10 5. Fats: Omega-3 (but fish is better), olive oil 6. Microflora and probiotic yogurts, resistent starch. 7. Curcumin 8. Flavonoids in chocolate Antioxidants - now their benefits are under question Resveratrol Experimental supplements are under question (C60 and so on) Healthy sleep 1. While sleeping, regeneration occurs 2. Orthopaedically “correct,” comfortable bed 3. Lack of light exposure 4. Gentle alarm 5. Fresh Air 6. Emotional comfort (cat, music) 7. Positive dreams 8. Lack of sleep apnea Control important parameters Mortality is strongly associated with some parameters: 1. Reduce blood pressure (Q10, garlic, flavonoids, enalapril) 2. Weight loss 3. Control blood sugar 4. Control cholesterol 5. Reduce fatigue 6. Preservation of brain function 7. Strong muscles 8. Preserving mobility and balance (no falls) Hormone therapy has not been proven, there are risks 1. Age depleted hormons (testosteron) 2. Melatonin 3. Precursors of hormones: pregnenalon, DHEA Growth hormone is under question but many use it Hormesis Stimulation of repair via stress 1. Short fasting 2. Pouring cold water on the body 3. Sauna 4. Blood donation once a year Medications candidates in geroprotectors Principles 1. Before taking, consult with your doctor! Small doses! Assess the risk! 2. The older a person is, the more justified the risk: nothing to lose 3. During any treatment, choose drugs with data about life ex- tension abilities 4. Parallel participation in clinical trials Substances 1. The most proven lifeextenders. Metformin - (proven for dia- betics), aspirin, enalapril 2. Other candidates which need further analysis: Acarbose, Atsetiltsestin, Selegelin, Ibuprofen 3. Many antidepressants prolong life 4. Rapamycin (but can be dangerous) 5. Experimental drugs 6. NGF and its promoters (c) Alexey Turchin, 2015, CC3.0 license https://www.scribd.com/avturchin - all other roadmaps in last versions mailto: alexei.turchin@gmail.com http://immortality-roadmap.com/lifeextesionrus.pdf – russian version Medical Insurance 1. Coverage not less than one million dollars 2. Personal doctor 3. Regular check-ups are necessary 4. Insurance in a good country judged by the quality of its services ? 5. Personal savings and communication in hospitals (Russian Federation) 6. Active relatives 7. Obtaining citizenship of a country that provides free medical care (Israel) Avoidable medical errors and unnecessary medical interventions Proximity of reanimation and first aid ser- vices Substances Other methodsHealthy Lifestyle Complex life patterns which in- clude positive changes in the fol- lowing domains: sleep, sport, nutrition, hygiene, family. Such patterns which mean com- plex change in several domains may be: 1) interest group with strong bonds (vegetarian, semi-reli- gious, dog owning, sport club for running or hiking) 2) change life conditions – move to village, change occupation Prophylaxis of main deadly diseases Cardiovascular disease Diabetes Dementia Stroke Cancer Step 4 Brain health and dementia prevention Step 5 Slow aging and lower long term mortality First Full Bodily Check-Up 1. By doctor’s appointments 2. Excessive testing can be harmful Problems: fear, time, falseness ? 3. Need a regular full medical examination 4. Includes chest X-rays, CT scans, heart, co- lonoscopy, stomach, blood 5. Control blood level of consumed supplements Preventive interventions For some people in the second part of their life 1. Mastectomy for BRAC1 gene mutation carriers 2. Stents for coronary artery disease 3. Blood donations 4. Clean teeth Brain health Avoid concussions and injury Avoid brain toxic substances including alcohol Avoid hypertension and high sugar Green tea Vitamins B, E, A, D Study brain science Study new skills, especially motor ones Solve complex tasks Use everything known for intelligence improvement Brain regeneration NGF and BDNF promoting substances: Pure NGF in drops? Lion male Acetyl carnitine Blueberries Memantin Taurine Exercises which rise blood flow in the brain Complex tasks: run, walk, travel, social, dance Sleep TED talk link Cryonics Don’t forget to sign the cryonics contract Digital Immortality Constantly record videos about yourself Maintaining motivation 1. Like-minded people and books 2. Drawing up a personal plan 3. Public obligations Making the Decision 1. I can do this too! 2. Making the decision to extend one’s own life 3. Making this decision a top priority Awareness of the problem 1. Well, I’m getting old and will die soon! 2. But scientists can extend animals’ lives. 3. And some people live long lives and battle for life extension The growth of self-efficacy 1. Resources: material and social (money, connections, status, skills) 2. Being friends with scientists in the field of biology 3. General effectiveness: the ability to solve any kind of problems Planning 1. Create a skill for creating and executing plans 2. Proper medical choices 3. Instilling useful habits The State of Mind Required for Life Extension 1. Becoming a king in one’s own mind 2. A positive mood and outlook 3. Clear goals 3. Rationality 4. Control over pleasure, emotion and addictions Elimination of delusional beliefs about one’s own health 1. Ability to work with scientific literature 2. Rejecting unproven methods in favor of well proven ones 3. The ability to distinguish advertising from actual results 4. Rejecting homeopathy, unproven dietary supplements, pseudoscience Education 1. Reanimation, survival and basic medicine, like “How to survive choking” 2. Medicine and biology, biotechnology, brain sciences 3. Rationality and statistic 4. Constant update of your life extension plan based on new scientific discoveries (read Longecity) Step 6 Social activity Crowdfunding Crowd fund things that is really important to your health: Research in your disease Donate Donate to fundamental research in aging and life extension Donate SENS, Buck institute Promote Speak Be example Write posts Create art Political parties and lobbying Vote Money for research Altruism Participate in clinical trails Become a scientists Prevent x-risks Invest in life extension of over people (e.g. promote safety)