To perform operations with a microprocessor, instructions must specify the operation, data sources, and result destination. The Intel 8085 uses several addressing modes including direct addressing, register addressing, register indirect addressing, immediate addressing, and implicit addressing. Direct addressing specifies the operand address in the instruction itself. Register addressing uses register pairs to specify operands. Immediate addressing embeds the operand in the instruction. Implicit addressing operates on the accumulator without an explicit operand address.