This document discusses a proposed method for finding statistically significant co-location and segregation patterns in spatial domains. Existing approaches have shortcomings like relying on user thresholds and not accounting for spatial autocorrelation. The proposed method introduces a new definition of these patterns, models the null distribution of features to consider spatial autocorrelation, and designs an algorithm to find both types of patterns. It also develops strategies to reduce computational cost and further speed up the algorithm using neighborhood approximations. The method is empirically evaluated on synthetic and real data sets.