The document presents the 'Molecules of Knowledge' (MoK) model, which is a biochemically-inspired coordination framework aimed at enhancing self-organization in knowledge-intensive environments. It describes the challenges faced by knowledge workers in managing increasingly complex and diverse information and proposes a tuple-based approach that utilizes biochemical metaphors for knowledge aggregation and diffusion. The model is implemented using the Tucson coordination infrastructure, with a case study focusing on a self-organizing news repository demonstrating its potential applications.