CVS Caremark utilized lift modeling and constraint-based optimization to improve their POS coupon program. They developed predictive models to identify customers most likely to purchase incrementally in response to offers. Testing found their initial models did not improve results, but refining the models using more data and a combined analytic and strategic approach significantly increased incremental sales and profit per customer. Lessons included focusing on the right success metrics, challenges of lift modeling, and the need for both analytic techniques and business knowledge.