This document discusses optimization of scheduling constraints in manufacturing systems using heuristic procedures. It proposes a simple heuristic rule for staggering replenishments of products under an equal order interval method. This provides a formula to calculate the upper limit of maximum investment in inventory. The heuristic rule is shown to perform better than traditional Lagrange multiplier techniques by providing lower costs. An example is provided to illustrate determining optimal order quantities and sequences for machines and jobs using heuristic scheduling with layout constraints. The heuristic approach is concluded to provide better results than traditional methods while being easier to implement in real manufacturing situations.