The key events in speciation are the isolation of a population's gene pool, which can occur through external barriers like geographic separation, or internal barriers that develop later. External barriers initially isolate populations, exposing them to different environments where natural selection can cause adaptations. Over time, internal barriers to reproduction may form as a byproduct and further maintain genetic isolation between the species. Sympatric speciation differs in that internal barriers form first without an initial external cause, often through chromosome changes making organisms unable to mate.