Pathophy -Dengue Fever
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The document summarizes the pathophysiology of dengue fever. It involves the bite of the Aedes Aegypti mosquito, which transmits the dengue virus and allows it to penetrate the skin. The virus then infects and replicates inside Langerhans cells in the skin. Infected Langerhans cells travel to lymph nodes and alert the immune system. This leads to viremia as the virus spreads through the bloodstream. The immune response is activated, causing the release of pyrogens that trigger fever through the hypothalamus. It also causes an increase in blood pressure in vessels, resulting in the characteristic rash of dengue fever.
Pathophy -Dengue Fever
- 1. XI. Pathophysiology Modifiable • Non- Modifiable • Environment uncovered Gender stock water Bite of Aedes Aegypti Virus penetration to skin Virus infects and replicate inside the Langerhans cell (immunity of the skin) Langerhans cell release interferon (to limit the spread of infection) Infected Langerhans cells go to the lymphatic (alert the immune system) Then goes to the circulation Results in viremia (high level of virus in bloodstream) Activation of immune response Lymphocytes Neutrophils and White blood cells Release of pyrogen Reset of hypothalamus FEVER Increase blood pressure in vessel RASH 11