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Pathway 1: Under aerobic conditions, pyruvate is first converted into acetyl-CoA. The resultant
acetyl-CoA enters citric acid cycle. Citric acid yields a net gain of around 14 ATP (2.5 ATP per
NADH, and 1.5 ATP per FADH2) per pyruvate molecule.
Pathways 2: Under anaerobic condition (example- lactate fermentation in skeletal muscles,
ethanol fermentation in S. cereviseae, etc.), pyruvate enters fermentative pathways depending on
the organism, and sometime, the cultural conditions. Fermentation of pyruvate does not produce
ATP. However, it regenerates NAD+ required for glycolysis to keep going.
Solution
Pathway 1: Under aerobic conditions, pyruvate is first converted into acetyl-CoA. The resultant
acetyl-CoA enters citric acid cycle. Citric acid yields a net gain of around 14 ATP (2.5 ATP per
NADH, and 1.5 ATP per FADH2) per pyruvate molecule.
Pathways 2: Under anaerobic condition (example- lactate fermentation in skeletal muscles,
ethanol fermentation in S. cereviseae, etc.), pyruvate enters fermentative pathways depending on
the organism, and sometime, the cultural conditions. Fermentation of pyruvate does not produce
ATP. However, it regenerates NAD+ required for glycolysis to keep going.

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Pathway 1 Under aerobic conditions, pyruvate is first converted int.pdf

  • 1. Pathway 1: Under aerobic conditions, pyruvate is first converted into acetyl-CoA. The resultant acetyl-CoA enters citric acid cycle. Citric acid yields a net gain of around 14 ATP (2.5 ATP per NADH, and 1.5 ATP per FADH2) per pyruvate molecule. Pathways 2: Under anaerobic condition (example- lactate fermentation in skeletal muscles, ethanol fermentation in S. cereviseae, etc.), pyruvate enters fermentative pathways depending on the organism, and sometime, the cultural conditions. Fermentation of pyruvate does not produce ATP. However, it regenerates NAD+ required for glycolysis to keep going. Solution Pathway 1: Under aerobic conditions, pyruvate is first converted into acetyl-CoA. The resultant acetyl-CoA enters citric acid cycle. Citric acid yields a net gain of around 14 ATP (2.5 ATP per NADH, and 1.5 ATP per FADH2) per pyruvate molecule. Pathways 2: Under anaerobic condition (example- lactate fermentation in skeletal muscles, ethanol fermentation in S. cereviseae, etc.), pyruvate enters fermentative pathways depending on the organism, and sometime, the cultural conditions. Fermentation of pyruvate does not produce ATP. However, it regenerates NAD+ required for glycolysis to keep going.