This paper analyzes the effectiveness of different PID controller tuning methods for enhancing the performance of DC-DC converters in response to set-point changes and disturbances. Five tuning methods were tested, revealing variations in transient response and disturbance rejection capabilities for the PID controllers applied to a modeled DC-DC boost converter. The study's outcomes underscore the importance of robust PID tuning in ensuring tight voltage regulation despite variations in input supply and load conditions.