The document discusses strategies for revitalizing mature industry clusters. It begins by providing background on Development Agency East Netherlands (Oost NV), which focuses on strengthening the economy in East Netherlands. It then discusses several mature clusters in East Netherlands, including Food Valley, Health Valley, and Tech Valley. The document outlines some challenges with mature clusters, such as defending existing interests. It proposes strategies for revitalizing clusters, including increasing efforts in existing strategies, enlarging boundaries, and stimulating transsectoral innovations between clusters. It provides an example of a knowledge combination project called "Process on a Chip" that combined different research fields. Finally, it discusses using societal challenges as a way to mobilize businesses and provide innovative solutions.