Propose a pathway(s) to explain how the ectoderm and the notochord b.pdf
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The document discusses how the ectoderm and notochord inhibit the endoderm from expressing liver-specific genes during liver formation. It highlights the role of fox-a proteins, hhex, and prox1 in liver gene expression and notes that the loss of hhex can impair liver development. Additionally, it mentions that the ectoderm thickening and notochord mutants play crucial roles in blocking liver gene expression in the endoderm at early developmental stages.
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Propose a pathway(s) to explain how the ectoderm and the notochord b.pdf
- 1. Propose a pathway(s) to explain how the ectoderm and the notochord block the ability of the endoderm to express liver-specific genes during liver formation. Solution Some endodermal cells lie in the yolk sac of the cell, a subset of which move forward for the formation of the liver. Fox-A proteins are responsible for the expression of liver-specific genes It is the thickening of the intestinal rod tissues that is formed from the ectoderm that blocks the formation of inner organ tissue at the initial stage. Morphogenesis takes place to facilitate gene expression in the liver. The amniotes hhex and prox1 are responsible for liver gene expression. The loss of hhex can retard the formation of liver reduce its size. The mutants from the notochord block the endoderm to express liver-specific at the early stage liver formation.