PROTEIN STRUCTURE DATABANK
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This document discusses several protein databases and bioinformatics tools. It describes Protein Data Bank (PDB) as a repository for 3D structural data of proteins and nucleic acids overseen by wwPDB. National Center for Biotechnology Information (NCBI) provides access to biomedical and genomic databases. BLAST is a tool that compares sequences to databases to find similar regions and calculate statistical significance of matches. Swiss-Prot, PIR, and UniProt are comprehensive protein sequence databases that include functional information derived from literature. ExPASy is a bioinformatics resource portal offering databases and tools in areas like proteomics, genomics, and systems biology.
PROTEIN STRUCTURE DATABANK
- 8. 1. PROTEIN STRUCTURE 2. NCBI 3. DATABASES
- 11. Protein Database is a collection of sequences from several sources, including translations from annotated coding regions in Gen Bank, Ref Seq as well as records from SWISSPROT, PIR & PDB.
- 14. Finds regions of local similarity between sequences . Compares nucleotide or protein sequences to sequence databases. Calculates statistical significance from matches.
- 15. Can be used to infer functional and evolutionary relationships between sequences. It can also help in identifying members of the gene family .
- 17. Ex pert P rotein A nalysis Sy stemis a bioinformatics ExPASy resource portal operated by the Swiss Institute of Bioinformatics (SIB). The portal is aimed for both expert users and for people that are not familiar with a specific domain in life sciences.
- 18. Ex pert P rotein A nalysis Sy stem It provides access to scientific databases and software tools (i.e., resources) in different areas of life sciences including proteomics, genomics, phylogeny, systems biology, population genetics, transcriptomics etc. etc
- 19. 1. 2. 3. 4. 5. 6. 7. 8. 9. PROTEIN STRUCTURE NCBI DATABASES BLAST EXPASY PUB-MED SWISS-PROT PIR PDB
- 20. •SWISS-PROT also called UniProt is; a comprehensive, high-quality and freely accessible database of protein sequence and functional information. •Many entries are derived from genome sequencing projects.
- 21. SWISS-PROT • Contains a large amount of information about the biological function of proteins derived from the research literature. • The mission of UniProt is to provide the scientific community with a comprehensive, high-quality and freely accessible resource of protein sequence and functional information.
- 22. 1. 2. 3. 4. 5. 6. 7. 8. 9. PROTEIN STRUCTURE NCBI DATABASES BLAST EXPASY PUB-MED SWISS-PROT PIR PDB
- 23. PIR was established in 1984 by the National Biomedical Research Foundation (NBRF) as a resource to assist researchers in the identification and interpretation of protein sequence information. PIR has provided many protein databases and analysis tools freely accessible to the scientific community, including the Protein Sequence Database (PSD).
- 24. 1. 2. 3. 4. 5. 6. 7. 8. 9. PROTEIN STRUCTURE NCBI DATABASES SWISS-PROT PUB-MED EXPASY BLAST PIR PDB
- 26. Protein Data Bank (PDB) is a repository for the 3D structural data of large biological molecules, such as proteins and nucleic acids. PDB is overseen by an organization called the Worldwide Protein Data Bank, wwPDB. PDB is a key resource in areas of structural biology, such as structural genomics.