This document discusses guidelines for developing a good research question and refining existing questions. It provides principles for scientific research such as posing a significant empirical question, linking to theory, using appropriate methods, and generalizing findings. Well-crafted questions guide systematic planning and allow design of a study likely to answer the questions. A good research question should be linked to goals, identify populations and variables, determine needed study type, and influence data collection and number of participants. Writing good questions involves determining what to learn, drafting and revising with specificity and feedback, and building on prior work.