![Association Between Thyroid and Breast Cancers in Women
Matthew Brown[1]; Richard Boakye-Marfo[1]; Denise Johnson-Miller, MD, FACS[2];
Arthur Topilow, MD, FACP[1,4]; Alexander Shifrin, MD, FACS[2]; Danielle Lann, MD[4];
Yen-Hong Kuo, PhD[3] Patricia Greenberg, MS[3]; Mila Lachica, BA, CCRP[1,3]
[1]Axelrod Research Group, [2]Department of Surgery, [3]Office of Clinical Research, [4][Department of Medicine, Jersey Shore
University Medical Center Neptune, NJ
Objective
The objective of our study was to
analyze the timing and features of the
clinical and molecular presentation of
both thyroid and breast cancers that
arose in our study population by
examining the histology, dates of
diagnosis, treatments, prognostic
markers, genetics, and outcomes of
the patients with these two
malignancies.
Results
There were no triple negative breast
cancers seen in our study population.
There were not any medullary or
anaplastic thyroid cancers noted.
Thyroid cancer seemed to develop
later in life when associated with breast
cancer, while breast cancer seemed to
develop earlier in life when associated
with thyroid cancer. This was coupled
with significantly more cases seen
where the breast cancer developed
before the thyroid cancer. Finally, from
a genetic standpoint there was an
overall less aggressive collection of
cancers as we did not see any BRCA
mutations in the breast cancer patients
nor BRAF or MEN10 mutations in the
thyroid tumors. Also, often there was a
low average Ki-67 expression, as well
as a low rate of recurrence.
Methods
Our study population was comprised of
69 patients and was taken from the
JSUMC tumor registry and the private
office records of a staff physician
(A.S.). Those patients, between the
ages of 18 and 89, who were found to
have both breast and thyroid cancer,
with at least one cancer diagnosed
after 2000, were included in our review.
Acknowledgements
JSUMC Tumor Registry, Meridian
Surgical Associates
Background
Breast cancer remains the most
common cancer affecting women in the
United States. With that, breast cancer
patients who develop an additional
malignancy, either before or after their
breast neoplasm, often develop a
cancer of the thyroid.
Conclusion
The correlations seen in this small
study population, particularly in the
histological data, suggest that a
pathological cause for the development
of these malignancies is more likely as
opposed to the result of treatment-
related factors or observational bias.
With that, the study is limited due to
the missing data in some of the patient
reports. We maintain that surveillance
of these patients is important as a
result of the increased risk of
secondary malignancy. However, the
specific underlying mechanism
allowing both malignancies to develop
still remains obscure.
References
Inwald, E.C., Klinkhammer-Schalke,
M., Hofstadter, M., Zeman, F., Koller,
M., Gerstenhauer, M., Ortmann, O.
(2013). Ki-67 is a prognostic
parameter in breast cancer patients:
results of a large population based
cohort of a cancer registry. Breast
Cancer Research and Treatment,
139(2). Retrieved from
http://www.ncbi.nlm.nih.gov/pmc/artic
les/PMC3669503/
Kuo, J.H., Chabot, J.A., & Lee, J.A.
(2016). Breast cancer in thyroid
cancer survivors: An analysis of the
Surveillance, Epidemiology, and End
Results-9 database. Surgery, 159(1).
Retrieved from
http://www.ncbi.nlm.nih.gov/pubmed/
26522696
Liu, L., Shi, J., Mao, F., Wei, J., Fu, D.
& Zhang, J. (2015). Synchronous
primary cancers of the thyroid and
breast: A case report and review of
the literature. Oncology Letter, 9(1).
Retrieved from
http://www.ncbi.nlm.nih.gov/pmc/artic
les/PMC4246699/
71%
10%
3%
16%
Recurrence
None Breast Thyroid N/A
5
1
4
9
8
7
13
8 8
4
5
0
2
4
6
8
10
12
14
Under
40
40-44 45-49 50-54 55-59 60-64 65-69 70-74 75-80 Over 80 N/A
NumberofPatients
Age of Patient
Age at Breast Cancer Diagnosis
3 3
6
13
6
9
10
4
7
1
10
0
2
4
6
8
10
12
14
Under
40
40-44 45-49 50-54 55-59 60-64 65-69 70-74 75-80 Over 80 N/A
NumberofPatients
Age of Patient
Age at Thyroid Cancer Diagnosis
17%
46%
22%
15%
Order of Cancer Manifestation
Synchronous* BC First TC First N/A
52
9
8
Thyroid Cancer Histology
Papillary (includes Follicular variant type)
Follicular (includes Hurthle type)
N/A
35
10
8
2
1
13
Breast Cancer Histology
Ductal Carcinoma DCIS
Lobular Carcinoma LCIS
Papillary Carcinoma N/A](https://image.slidesharecdn.com/7774906f-be53-4fd2-ac55-5e7ca67fb030-160916220006/85/Research-Day-Poster-1-320.jpg)
Research Day Poster
- 1. Association Between Thyroid and Breast Cancers in Women Matthew Brown[1]; Richard Boakye-Marfo[1]; Denise Johnson-Miller, MD, FACS[2]; Arthur Topilow, MD, FACP[1,4]; Alexander Shifrin, MD, FACS[2]; Danielle Lann, MD[4]; Yen-Hong Kuo, PhD[3] Patricia Greenberg, MS[3]; Mila Lachica, BA, CCRP[1,3] [1]Axelrod Research Group, [2]Department of Surgery, [3]Office of Clinical Research, [4][Department of Medicine, Jersey Shore University Medical Center Neptune, NJ Objective The objective of our study was to analyze the timing and features of the clinical and molecular presentation of both thyroid and breast cancers that arose in our study population by examining the histology, dates of diagnosis, treatments, prognostic markers, genetics, and outcomes of the patients with these two malignancies. Results There were no triple negative breast cancers seen in our study population. There were not any medullary or anaplastic thyroid cancers noted. Thyroid cancer seemed to develop later in life when associated with breast cancer, while breast cancer seemed to develop earlier in life when associated with thyroid cancer. This was coupled with significantly more cases seen where the breast cancer developed before the thyroid cancer. Finally, from a genetic standpoint there was an overall less aggressive collection of cancers as we did not see any BRCA mutations in the breast cancer patients nor BRAF or MEN10 mutations in the thyroid tumors. Also, often there was a low average Ki-67 expression, as well as a low rate of recurrence. Methods Our study population was comprised of 69 patients and was taken from the JSUMC tumor registry and the private office records of a staff physician (A.S.). Those patients, between the ages of 18 and 89, who were found to have both breast and thyroid cancer, with at least one cancer diagnosed after 2000, were included in our review. Acknowledgements JSUMC Tumor Registry, Meridian Surgical Associates Background Breast cancer remains the most common cancer affecting women in the United States. With that, breast cancer patients who develop an additional malignancy, either before or after their breast neoplasm, often develop a cancer of the thyroid. Conclusion The correlations seen in this small study population, particularly in the histological data, suggest that a pathological cause for the development of these malignancies is more likely as opposed to the result of treatment- related factors or observational bias. With that, the study is limited due to the missing data in some of the patient reports. We maintain that surveillance of these patients is important as a result of the increased risk of secondary malignancy. However, the specific underlying mechanism allowing both malignancies to develop still remains obscure. References Inwald, E.C., Klinkhammer-Schalke, M., Hofstadter, M., Zeman, F., Koller, M., Gerstenhauer, M., Ortmann, O. (2013). Ki-67 is a prognostic parameter in breast cancer patients: results of a large population based cohort of a cancer registry. Breast Cancer Research and Treatment, 139(2). Retrieved from http://www.ncbi.nlm.nih.gov/pmc/artic les/PMC3669503/ Kuo, J.H., Chabot, J.A., & Lee, J.A. (2016). Breast cancer in thyroid cancer survivors: An analysis of the Surveillance, Epidemiology, and End Results-9 database. Surgery, 159(1). Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/ 26522696 Liu, L., Shi, J., Mao, F., Wei, J., Fu, D. & Zhang, J. (2015). Synchronous primary cancers of the thyroid and breast: A case report and review of the literature. Oncology Letter, 9(1). Retrieved from http://www.ncbi.nlm.nih.gov/pmc/artic les/PMC4246699/ 71% 10% 3% 16% Recurrence None Breast Thyroid N/A 5 1 4 9 8 7 13 8 8 4 5 0 2 4 6 8 10 12 14 Under 40 40-44 45-49 50-54 55-59 60-64 65-69 70-74 75-80 Over 80 N/A NumberofPatients Age of Patient Age at Breast Cancer Diagnosis 3 3 6 13 6 9 10 4 7 1 10 0 2 4 6 8 10 12 14 Under 40 40-44 45-49 50-54 55-59 60-64 65-69 70-74 75-80 Over 80 N/A NumberofPatients Age of Patient Age at Thyroid Cancer Diagnosis 17% 46% 22% 15% Order of Cancer Manifestation Synchronous* BC First TC First N/A 52 9 8 Thyroid Cancer Histology Papillary (includes Follicular variant type) Follicular (includes Hurthle type) N/A 35 10 8 2 1 13 Breast Cancer Histology Ductal Carcinoma DCIS Lobular Carcinoma LCIS Papillary Carcinoma N/A