This document discusses optimization-based calibration of traffic simulation models. It introduces the SASCO (Sensitivity Analysis, Self-Calibration, and Optimization) architecture, which uses directed brute force or Simultaneous Perturbation Stochastic Approximation to efficiently calibrate traffic simulations. The paper assesses the qualities of these two optimization methods using synthetic and real-world case studies to determine when each is best applied. Regardless of the optimization method used, the SASCO architecture offers an improved level of calibration efficiency for practical application.