Secure your IT infrastructure with GNU/Linux outlines a strategy for migrating core services like email, web, and file sharing to open source alternatives like Postfix, Apache, and Samba. It discusses implementing email servers, clients and antivirus/spam protection with Sendmail, Horde, ClamAV and SpamAssassin. The document also recommends securing services with firewalls like IPTables and SELinux, and replacing proprietary databases, VOIP, and desktop software with open source options like MySQL, PostgreSQL, Asterisk, Thunderbird and OpenOffice. Finally, it suggests using distributions like Ubuntu Server, CentOS or Debian for servers and Ubuntu, Fedora or Open SUSE for desktop clients.