This document analyzes the seismic response of regular and irregular buildings with vertical irregularities using STAAD.Pro software. Six building models are analyzed - three regular buildings with stepped, inverted-T, and U-shaped vertical irregularities, and three irregular (H-shaped plan) buildings with the same vertical irregularities. Response spectrum analysis is used to determine maximum displacements, base shear, frequencies, and time periods. Results show irregular buildings have higher displacements and lower frequencies than regular buildings. The regular building with a U-shaped vertical irregularity performed the worst with the highest displacements. In conclusion, regular buildings performed better seismically than irregular buildings with vertical irregularities.