This document summarizes a study on seismic analysis of a 50-story irregular reinforced concrete (RC) framed structure. Various types of structural irregularities were considered, including mass irregularity, vertical geometric irregularity, re-entrant corners, diaphragm discontinuity, and stiffness irregularity. The structure was modeled and analyzed using ETABS software. Results showed increased seismic responses like displacement, drift, and period for irregular structures compared to a regular structure. Specifically, the re-entrant corner structure performed worst with highest displacement and drift due to its irregular geometry. Mass irregularity resulted in highest base shear. Stiffness irregularity led to longest period. In conclusion, regular structures performed better than irregular structures under seismic loads