This document summarizes a study on the behavior of tall reinforced concrete (RC) structures with vertical irregularities (setbacks and mass irregularities) under lateral loads. Various 30-story RC building models were analyzed using ETABS 2013 software, including regular, setback, and mass irregular models for Seismic Zones 5 and 2. Parameters like story displacement, drift, stiffness, base shear, and time period were compared. Results showed that structures with setbacks or mass irregularities experienced increased displacements, drifts, and base shears compared to regular structures, with greater effects in Zone 5. Irregular structures are more vulnerable to damage from earthquakes.