This document discusses a study investigating the effect of soil-structure interaction on buildings with mass irregularity under seismic loads. A finite element model was created in SAP 2000 to model the soil-structure interaction of framed buildings founded on different soil types (hard, medium, soft). Response spectrum analysis was conducted. Parameters like time period, base shear, roof displacement, and story drift were compared between regular buildings and buildings with mass irregularity located at the bottom, middle, or top stories. The results showed that for buildings with mass irregularity, the time period, roof displacement, and story drift increased while the base shear decreased compared to regular buildings, with a greater effect for softer soil types and mass located higher in the building.