The document summarizes a study on the effect of infill and mass irregularity on the seismic performance of reinforced concrete buildings. Nine building models were analyzed, including regular bare frame models and models with irregularities due to partial masonry infill or additional mass at certain floors. Response spectrum analysis was conducted on the models and responses like displacement, drift, overturning moment, shear force and stiffness were compared. The results showed that infill walls enhance seismic performance by reducing displacement and drift, while increasing stiffness, but cause higher forces. Mass irregularity increased displacement, drift and forces in intermediate floors but had little effect at the top and bottom. Irregular buildings generally performed poorer under seismic loading than the regular bare frame model.