This document presents the results of a study analyzing the seismic performance of reinforced concrete framed structures with different plan configurations (regular vs. irregular) and the presence or absence of a soft story. 12 structural models were analyzed using SAP2000 software, considering seismic zones II and V. The results showed that structures with an irregular plan and without masonry infill walls experienced the highest displacements and drifts. Structures with a soft story also had increased drifts. Infill walls increased base shear and stiffness, resulting in lower displacements. Overall, regular structures with masonry infill performed best seismically.