This document presents a study comparing the seismic response of regular and geometrically irregular multi-story reinforced concrete buildings. A 9-story building model with and without column size irregularities is analyzed using ETABS software. Results show increased story drift, displacement and storey shear in the irregular building model compared to the regular one, indicating poorer seismic performance. Irregularities in a building's mass, stiffness and strength distribution can concentrate stresses, increasing vulnerability during earthquakes. Regular buildings with consistent layouts generally experience less damage.