Sequence Services Phase 2 Webinar Series: Constellation Technology and Genestack
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Constellation Technologies and Genestack have developed Sequence Services within the Constellation Framework, focusing on delivering big data and bioinformatics solutions through a flexible cloud platform. The goal is to create a scalable environment for bioinformatics applications, enabling integration with existing systems and customizable workflows while reducing support costs. Achievements include a managed portal with essential web services, integrated applications, and initial collaboration with Genestack for enhanced bioinformatics tools.
Sequence Services Phase 2 Webinar Series: Constellation Technology and Genestack
- 1. Constellation Technologies & GeneStack Development of Sequence Services 2 in the Constellation Framework 1
- 2. Constellation Experts in big data and bioinformatics • Spin out from STFC (Science and Technology Facilities Council) – Largest research facility in UK specialising in large data computing • CERN, European physics and astronomy science • Supporting all UK disciplines in computing • Strong IT & Bioinformatics expertise – Strong Bioinformatics delivery expertise – Strong connections into European academia – Excellent access to newly developed applications, tools and algorithms • Supplier of cloud computing services to large Pharma. • Partners for Pistoia SS2 – Microsoft Azure – STFC 2
- 3. Constellation’s “Roadmap” Text Genome Mining/Search Analysis Core Data “AppMarket” Integration Service Service Service Service “Workflow Management” API Seamless Integration with Client systems
- 4. Bioinformatics IT • Bioinformatics • IT – Novel Algorithms – Platform Design – Research – Support – Scientific support – Maintenance – Discovery – Testing – Analysis – Stability / Scalability – Value Added – Security 4
- 5. Hosting Cloud • Hosted • Cloud – Single Vendor – Vendor Agnostic – Hardware limitations – As required – Restricted storage – Selectable storage – Limited cost models – Best model available – “Lock in” – “Flexible” 5
- 6. Cloud Vision Flexible Flexible Compute Storage Vendor Agnostic Academic or Client bespoke Business solutions Logic Client Minimise Applications Support Virtual “Bioinformatics Organisation Marketplace” True Cloud 6
- 7. High Level Architecture Portal Bioinformatics Deployed Workflow UI UIs Workflow (Apps) Bioinformatics Workflow Tools Systems Bioinformatics Applications Distributed Compute Distributed Storage
- 8. Our goal for SS2 • We believed the end goal was a flexible platform where ALL the application described in SS2 scope could be deployed for individual clients as required. • Platform should be scalable where security, support and maintenance can be easily managed. – Reducing support costs allows for more focus on research • Bioinformatics applications added as required: – GeneStack (Analysis Portal) – VIB (Arctix) (Workflow) (in discussion) – EBI (Services) (in discussion) • Workflow delivered as a fundamental development principle • Development of the “AppMarket” for Bioinformatics 8
- 9. Secure Scalable Storage Company Workflow Specific Core Integrating 3rd Party Systems Integration Future With other Development Systems 9
- 10. Deliverables achieved • Portal with access to all the “Must Have” Web Services described in the SS2 documentation – Constellation Managed Administration Interface to allow organisational mapping of users to Programs / Projects / Applications • “Tool Box” of Integrated Applications – Galaxy – Secure Ensembl – Secure CellProfiler – Content Search (New development) • Galaxy workflow engine with integrating applications deployed as a secure web application to cover “Must Have” tools – Restricted set of apps based on feedback from “testing pool” (Restrictions based on Need/Security) – Tools can be added on request • Scalable storage and compute (dependant on need and security) – Structured Program - Project – User mapping – Cost effective data storage and compute • Initial Integration with another Bioinformatics Vendor (GeneStack) 10
- 11. Other Available SAAS tools • Secure EnsEMBL – Private copy of EnsEMBL (Rackspace) – Secure UI and API Access – Ability to map DAS (secure or Public) • Parallelised CellProfiler – Private scalable version of CellProfiler on Azure 11