The document presents a methodology for optimizing both active and standby energy in 22nm sub-threshold CMOS circuits, focusing on reducing leakage power consumption due to technology scaling. Through a dual threshold voltage design and a slack-based genetic algorithm, the study shows how implementation can yield energy savings of 14.5% to 42.28% for active energy and 62.8% to 67% for standby power across various benchmark circuits. The approach enhances the efficiency of sub-threshold circuits for energy-constrained applications while addressing performance challenges related to delay.